P2 receptors expressed by blood cells
| Cell type . | P2Y . | P2X . | Reference no. . |
|---|---|---|---|
| Rat/mouse peritonel macrophages | P2Y | P2X7 | 49,77, 79-82, 94 |
| BAC1.2F5 macrophages | P2Y | P2X7-like | 83 |
| RAW 264.7 macrophages | P2Y | P2X7-like | 81, 116 |
| J774 macrophages | P2Y | P2X7 | 60,75-77 |
| THP-1 macrophages | P2Y2 | P2X7 | 5,88 |
| KG-1 myeloblastic cells | P2Y1 | 192 | |
| HL-60 myeloid cells | P2Y2, P2Y11 | P2X1 | 39, 192, 232 |
| U937 monocytes | P2Y2, P2Y6 | 5 | |
| Human monocytes | P2Y1, P2Y2, P2Y4, P2Y6 | 5, 89 | |
| Human macrophages | P2Y | P2X7 | 77, 79, 89 |
| FSDC | P2Y | P2X7 | 141 |
| Mouse dendritic cells* | P2X7 | 141 | |
| Human dendritic cells† | P2Y1, P2Y2, P2Y4, P2Y6, P2Y11 | P2X1, P2X4, P2X5, P2X7 | 139, 140, 142 |
| Human Langerhans' cells‡ | P2X7-like | 136 | |
| Human dendritic cells2-153 | P2X7 | 55, 137 | |
| P-815 mastocytoma | P2X7-like | 132 | |
| YAC lymphoma cells | P2X7-like | 132 | |
| Mouse lymphocytes | P2X7 | 49, 155, 166 | |
| Murine thymocytes | P2Y1, P2Y2 | P2X1 | 164, 165, 167,168 |
| Human B lymphocytes | P2Y | P2X7 | 154, 158, 160, 161,162 |
| Human T lymphocytes | P2X1, P2X4, P2X7 | 163, O.R.B. et al, unpublished data, 1999 | |
| Human PMN | P2Y4, P2Y6 | P2X7 | 5, 49 |
| Human platelets | P2Y1 | P2X1 | 204-209 |
| Erythrocytes | P2Y1 | P2X7-like | 224,225 |
| RBL and rat mast cells | P2Y | P2X7-like | 58, 59, 230,231 |
| Mouse hemopoietic precursors | P2X7-like | 228,229 |
| Cell type . | P2Y . | P2X . | Reference no. . |
|---|---|---|---|
| Rat/mouse peritonel macrophages | P2Y | P2X7 | 49,77, 79-82, 94 |
| BAC1.2F5 macrophages | P2Y | P2X7-like | 83 |
| RAW 264.7 macrophages | P2Y | P2X7-like | 81, 116 |
| J774 macrophages | P2Y | P2X7 | 60,75-77 |
| THP-1 macrophages | P2Y2 | P2X7 | 5,88 |
| KG-1 myeloblastic cells | P2Y1 | 192 | |
| HL-60 myeloid cells | P2Y2, P2Y11 | P2X1 | 39, 192, 232 |
| U937 monocytes | P2Y2, P2Y6 | 5 | |
| Human monocytes | P2Y1, P2Y2, P2Y4, P2Y6 | 5, 89 | |
| Human macrophages | P2Y | P2X7 | 77, 79, 89 |
| FSDC | P2Y | P2X7 | 141 |
| Mouse dendritic cells* | P2X7 | 141 | |
| Human dendritic cells† | P2Y1, P2Y2, P2Y4, P2Y6, P2Y11 | P2X1, P2X4, P2X5, P2X7 | 139, 140, 142 |
| Human Langerhans' cells‡ | P2X7-like | 136 | |
| Human dendritic cells2-153 | P2X7 | 55, 137 | |
| P-815 mastocytoma | P2X7-like | 132 | |
| YAC lymphoma cells | P2X7-like | 132 | |
| Mouse lymphocytes | P2X7 | 49, 155, 166 | |
| Murine thymocytes | P2Y1, P2Y2 | P2X1 | 164, 165, 167,168 |
| Human B lymphocytes | P2Y | P2X7 | 154, 158, 160, 161,162 |
| Human T lymphocytes | P2X1, P2X4, P2X7 | 163, O.R.B. et al, unpublished data, 1999 | |
| Human PMN | P2Y4, P2Y6 | P2X7 | 5, 49 |
| Human platelets | P2Y1 | P2X1 | 204-209 |
| Erythrocytes | P2Y1 | P2X7-like | 224,225 |
| RBL and rat mast cells | P2Y | P2X7-like | 58, 59, 230,231 |
| Mouse hemopoietic precursors | P2X7-like | 228,229 |
P2 receptor expression is based on functional and pharmacologic evidence, mRNA detection by reverse transcriptase–polymerase chain reaction, or reactivity with specific antibodies. For P2Y receptors, lack of a subscript indicates that, although functional and pharmacologic data show expression of P2Y receptors, the individual P2Y subtypes have not been yet identified. For P2X receptors, “P2X7-like” means that functional and pharmacologic evidence strongly suggest expression of P2X7, but molecular data are missing. Failure to list a P2Y or P2X receptor for a given cell type means that there is lack of evidence for its expression, whether at the functional, pharmacologic, or molecular level.
FSCD indicates fetal skin–derived dendritic cell; PMN, polimorphonuclear; RBL, rat basophilic leukemia.
Derived from bone marrow.
Derived from blood precursors.
Derived from epidermis.
Derived from tonsils and lymph nodes.