Patient and disease characteristics
N | 86 |
Median age, y (range) | 52 (22-70) |
Sex | 52 M, 34 F |
Diagnosis and status at transplantation | |
AML/MDS | 43 |
CR1 | 1 |
Untreated 1st relapse | 10 |
Remission ≥ CR2 | 5 |
Refractory | 27 |
CML | 27 |
CR1 | 6 |
Transformed | 21 |
ALL/lymphoma | 16 |
Remission ≥ CR2 | 1 |
Refractory | 15 |
Median no. prior therapies (range) | 3 (0-8) |
Median time to transplantation, d (range) | 553 (27-6627) |
Prior transplantation | 24 |
Autologous | 16 |
Allogeneic different donor | 5 |
Allogeneic same donor | 3 |
Donor type | |
6 of 6 Matched related | 39 |
5 of 6 Mismatched related | 7 |
6 of 6 Matched unrelated | 40 |
Stem cell source | |
Bone marrow | 52 |
Peripheral blood | 34 |
CMV Status | |
Neg/neg | 6 |
Donor/recipient sex | |
Donor F/recipient M | 23 |
Donor F/recipient F | 19 |
Other | 44 |
Preparative regimen | |
Fludarabine/melphalan 180 | 66 |
Fludarabine/melphalan 140 | 12 |
Cladribine/melphalan 180 | 8 |
GVHD prophylaxis | |
Tacrolimus/methotrexate | 81 |
Other | 5 |
N | 86 |
Median age, y (range) | 52 (22-70) |
Sex | 52 M, 34 F |
Diagnosis and status at transplantation | |
AML/MDS | 43 |
CR1 | 1 |
Untreated 1st relapse | 10 |
Remission ≥ CR2 | 5 |
Refractory | 27 |
CML | 27 |
CR1 | 6 |
Transformed | 21 |
ALL/lymphoma | 16 |
Remission ≥ CR2 | 1 |
Refractory | 15 |
Median no. prior therapies (range) | 3 (0-8) |
Median time to transplantation, d (range) | 553 (27-6627) |
Prior transplantation | 24 |
Autologous | 16 |
Allogeneic different donor | 5 |
Allogeneic same donor | 3 |
Donor type | |
6 of 6 Matched related | 39 |
5 of 6 Mismatched related | 7 |
6 of 6 Matched unrelated | 40 |
Stem cell source | |
Bone marrow | 52 |
Peripheral blood | 34 |
CMV Status | |
Neg/neg | 6 |
Donor/recipient sex | |
Donor F/recipient M | 23 |
Donor F/recipient F | 19 |
Other | 44 |
Preparative regimen | |
Fludarabine/melphalan 180 | 66 |
Fludarabine/melphalan 140 | 12 |
Cladribine/melphalan 180 | 8 |
GVHD prophylaxis | |
Tacrolimus/methotrexate | 81 |
Other | 5 |
y indicates years; M, male; F, female; AML, acute myelogenous leukemia; MDS, myelodysplastic syndromes; CR, chronic phase; CML, chronic myelogenous leukemia; ALL, acute lymphoblastic leukemia; d, days; CMV, cytomegalovirus; Neg, negative; GVHD, graft-versus-host disease.