Antigenicity of fVIII C2 mutants toward C2-specific inhibitory antibodies compared with human fVIII
| Mutant . | Antigenicity* . | ||
|---|---|---|---|
| Less . | Equal . | More . | |
| Met2199Ile | 4/7 | 0/7 | 3/7 |
| Phe2200Leu | 4/7 | 2/7 | 1/7 |
| Val2223Ala | 0/7 | 2/7 | 5/7 |
| Lys2227Glu | 2/7 | 1/7 | 4/7 |
| Leu2252Phe | 4/7 | 3/7 | 0/7 |
| Met2199Ile/Phe2200Leu | 6/7 | 1/7 | 0/7 |
| Val2223Ala/Lys2227Glu | 4/7 | 1/7 | 2/7 |
| Met2199Ile/Phe2200Leu Val2223Ala/Lys2227Glu | 7/7 | 0/7 | 0/7 |
| HP20 | 7/7 | 0/7 | 0/7 |
| Mutant . | Antigenicity* . | ||
|---|---|---|---|
| Less . | Equal . | More . | |
| Met2199Ile | 4/7 | 0/7 | 3/7 |
| Phe2200Leu | 4/7 | 2/7 | 1/7 |
| Val2223Ala | 0/7 | 2/7 | 5/7 |
| Lys2227Glu | 2/7 | 1/7 | 4/7 |
| Leu2252Phe | 4/7 | 3/7 | 0/7 |
| Met2199Ile/Phe2200Leu | 6/7 | 1/7 | 0/7 |
| Val2223Ala/Lys2227Glu | 4/7 | 1/7 | 2/7 |
| Met2199Ile/Phe2200Leu Val2223Ala/Lys2227Glu | 7/7 | 0/7 | 0/7 |
| HP20 | 7/7 | 0/7 | 0/7 |
Significantly different at the 99% confidence level.