Serum level of IL-3 and GM-CSF in mice
| Mouse group . | Mice, no. . | IL-3 (pg/mL)* . | GM-CSF (pg/mL)* . |
|---|---|---|---|
| Normal/vector control | 8 (6/2)† | < 2.5‡ | < 51-153 |
| Bcr-Abl/p210 | 3 | 7.8 ± 2.4 | 24.7 ± 9.6 |
| R1057K/p210 | 6 | 5.2 ± 2.7 (0.107)1-155 | 22.5 ± 9.4 (0.378)1-155 |
| ΔSH2/p210 | 12 | 7.6 ± 5.2 (0.473)1-155 | 17.5 ± 7.8 (0.096)1-155 |
| WBC containing < 18% B cells | 5 | 8.8 ± 8.0 | 23.4 ± 4.0 |
| WBC containing ≥ 18% B cells | 7 | 6.8 ± 2.2 (0.302)1-154 | 13.3 ± 7.2 (0.006)1-154 |
| Mouse group . | Mice, no. . | IL-3 (pg/mL)* . | GM-CSF (pg/mL)* . |
|---|---|---|---|
| Normal/vector control | 8 (6/2)† | < 2.5‡ | < 51-153 |
| Bcr-Abl/p210 | 3 | 7.8 ± 2.4 | 24.7 ± 9.6 |
| R1057K/p210 | 6 | 5.2 ± 2.7 (0.107)1-155 | 22.5 ± 9.4 (0.378)1-155 |
| ΔSH2/p210 | 12 | 7.6 ± 5.2 (0.473)1-155 | 17.5 ± 7.8 (0.096)1-155 |
| WBC containing < 18% B cells | 5 | 8.8 ± 8.0 | 23.4 ± 4.0 |
| WBC containing ≥ 18% B cells | 7 | 6.8 ± 2.2 (0.302)1-154 | 13.3 ± 7.2 (0.006)1-154 |
Results shown as average ± SD.
Six age-matched normal mice and 2 vector control mice.
Sensitivity of IL-3 ELISA kit was less than 2.5 pg/mL IL-3.
Sensitivity of GM-CSF ELISA kit was less than 5 pg/mL GM-CSF.
The possibility value of Student t test comparing with wild-type Bcr-Abl mice.
The possibility value of Student t test between the 2 groups within ΔSH2 mice.