Table 1. Clinicopathologic features of... | American Society of Hematology

Table 1.

Clinicopathologic features of recipients of p210 R1053K-transduced marrow before death

Mouse	Day after transplantation
Mouse	Day 22	Day 28	Day 35	Death (day)
p210 R1053K #2				(day 38)
Pb WBC^*	ND	99 000	ND	4 000
Differential^†		33% myeloid		90% lymphoblasts
Spleen size^‡		++		0.34 g
p210 R1053K #4				(day 40)
Pb WBC^*	ND	345 000	ND	ND
Differential^†		14% myeloid
Spleen size^‡		+++		0.41 g
p210 R1053K #5				(day 41)
Pb WBC^*	ND	195 000	ND	4 800
Differential^†		31% myeloid		90% lymphoblasts
Spleen size^‡		+++		0.42 g
p210 R1053K #6				(day 42)
Pb WBC^*	67 000	ND	90 000	ND
Differential^†	30% myeloid		60% myeloid
Spleen size^‡	++		++	0.5 g

Mouse	Day after transplantation
Mouse	Day 22	Day 28	Day 35	Death (day)
p210 R1053K #2				(day 38)
Pb WBC^*	ND	99 000	ND	4 000
Differential^†		33% myeloid		90% lymphoblasts
Spleen size^‡		++		0.34 g
p210 R1053K #4				(day 40)
Pb WBC^*	ND	345 000	ND	ND
Differential^†		14% myeloid
Spleen size^‡		+++		0.41 g
p210 R1053K #5				(day 41)
Pb WBC^*	ND	195 000	ND	4 800
Differential^†		31% myeloid		90% lymphoblasts
Spleen size^‡		+++		0.42 g
p210 R1053K #6				(day 42)
Pb WBC^*	67 000	ND	90 000	ND
Differential^†	30% myeloid		60% myeloid
Spleen size^‡	++		++	0.5 g

WBC = white blood cell; Pb = peripheral blood; ND = not done.

Peripheral blood leukocyte count (per μL).

Percentage of maturing myeloid cells (CD11b⁺) or lymphoblasts (B220⁺) assessed by morphology or FACS.

Assessed by palpation: ++ easily palpable; +++ greatly enlarged.