Results of the bcl-2–JH PCR analysis on day 50 and clinical outcome (n = 30)
. | Patient number . | CR/CRu . | PR . | SD/Prog . | Progression at 12 months* . |
---|---|---|---|---|---|
Peripheral blood PCR negative | 17 | 10‡ | 4 | 3 | 1 |
With BM PCR negative | 9 | 5 | 3 | 1 | 0 |
With BM PCR positive | 7 | 4 | 1 | 2 | 1 |
With BM untested | 1 | 1 | 0 | 0 | 0 |
Peripheral blood PCR positive† | 13 | 0 | 9 | 4 | 8 |
. | Patient number . | CR/CRu . | PR . | SD/Prog . | Progression at 12 months* . |
---|---|---|---|---|---|
Peripheral blood PCR negative | 17 | 10‡ | 4 | 3 | 1 |
With BM PCR negative | 9 | 5 | 3 | 1 | 0 |
With BM PCR positive | 7 | 4 | 1 | 2 | 1 |
With BM untested | 1 | 1 | 0 | 0 | 0 |
Peripheral blood PCR positive† | 13 | 0 | 9 | 4 | 8 |
Only 30 of 32 patients with bcl-2–JH rearrangement at diagnosis were evaluated on day 50.
2-tailed Fisher exact test for comparison of PCR analysis on day 50 and clinical outcome at 12 months (P < .0001).
All patients who were PCR positive in peripheral blood were also PCR positive in bone marrow, except 2 untested in bone marrow.
2-tailed Fisher exact test for comparison of PCR analysis on day 50 and clinical outcome on day 78 (P < .0001).