Adverse effects of liposomal ATRA in the 69 patients enrolled
| Adverse effect . | Total no. (%) . | Grade 3/4 no. (%) . |
|---|---|---|
| ATRA syndrome | 18 (26%) | 10 (15%) |
| Leukocytosis (WBC > 10 000 cells/μL) | 35 (51%) | |
| Headache | 46 (67%) | 10 (15%) |
| Dry skin | 23 (33%) | |
| Hypertriglyceridemia | 23 (33%) | 4 (5.8%) |
| Fever | 18 (26%) | |
| Nausea | 13 (19%) | |
| Stomatitis | 11 (16%) | |
| Vomiting | 10 (15%) | |
| Chelitis | 9 (13%) | |
| Exfoliative dermatitis | 9 (13%) | |
| Rash | 8 (12%) | |
| Myalgia | 8 (12%) | |
| Liver enzymes abnormalities | 7 (10%) | |
| Bone pain | 6 (9%) | 2 (3%) |
| Arthralgia | 5 (7%) | |
| Elevated LDH | 4 (6%) | |
| Pseudotumor cerebri | 4 (6%) | 3 (4%) |
| Hypercholesteremia | 4 (6%) | |
| Chills | 4 (6%) | |
| Pruritus | 3 (4%) | |
| Diarrhea | 2 (3%) |
| Adverse effect . | Total no. (%) . | Grade 3/4 no. (%) . |
|---|---|---|
| ATRA syndrome | 18 (26%) | 10 (15%) |
| Leukocytosis (WBC > 10 000 cells/μL) | 35 (51%) | |
| Headache | 46 (67%) | 10 (15%) |
| Dry skin | 23 (33%) | |
| Hypertriglyceridemia | 23 (33%) | 4 (5.8%) |
| Fever | 18 (26%) | |
| Nausea | 13 (19%) | |
| Stomatitis | 11 (16%) | |
| Vomiting | 10 (15%) | |
| Chelitis | 9 (13%) | |
| Exfoliative dermatitis | 9 (13%) | |
| Rash | 8 (12%) | |
| Myalgia | 8 (12%) | |
| Liver enzymes abnormalities | 7 (10%) | |
| Bone pain | 6 (9%) | 2 (3%) |
| Arthralgia | 5 (7%) | |
| Elevated LDH | 4 (6%) | |
| Pseudotumor cerebri | 4 (6%) | 3 (4%) |
| Hypercholesteremia | 4 (6%) | |
| Chills | 4 (6%) | |
| Pruritus | 3 (4%) | |
| Diarrhea | 2 (3%) |
See Table 5 for abbreviations.
All 69 enrolled patients were evaluated for toxicity.