Framework for understanding the pathologic effects of immunoglobulin G antiplatelet antibodies in immune-mediated thrombocytopenia
| Nonactivating IgG antibody . | Activating IgG antibody . |
|---|---|
| Splenic clearance | Interplay of splenic clearance and intravascular platelet activation |
| Thrombocytopenia | Thrombocytopenia |
| Thrombosis and/or mediator release | |
| Local and/or systemic effects |
| Nonactivating IgG antibody . | Activating IgG antibody . |
|---|---|
| Splenic clearance | Interplay of splenic clearance and intravascular platelet activation |
| Thrombocytopenia | Thrombocytopenia |
| Thrombosis and/or mediator release | |
| Local and/or systemic effects |
IgG indicates immunoglobulin G.