Table 1. Difference in degree of... | American Society of Hematology

Table 1.

Difference in degree of thrombocytopenia and presence of shock phenotype following treatment with 50 μg anti-CD9 antibody in different defined mouse lines

Mouse line	Degree of thrombocytopenia^*	Shock phenotype
Wild type	Moderate	No
IIA tg	Severe	No
γ-KO	None	No
IIA tg × γ-KO	Severe	Yes (fatal 16/18)
IIA tg × γ-KO, lower dose antibody	Moderate	No
IIA tg low expressors (± γ-KO)	Moderate	No
IIA tg after 2.4G2 spleen FcγR blockade	Severe	Yes
IIA tg after splenectomy	ND^†	Yes

Mouse line	Degree of thrombocytopenia^*	Shock phenotype
Wild type	Moderate	No
IIA tg	Severe	No
γ-KO	None	No
IIA tg × γ-KO	Severe	Yes (fatal 16/18)
IIA tg × γ-KO, lower dose antibody	Moderate	No
IIA tg low expressors (± γ-KO)	Moderate	No
IIA tg after 2.4G2 spleen FcγR blockade	Severe	Yes
IIA tg after splenectomy	ND^†	Yes

tg indicates transgenic; KO, knockout.

Moderate thrombocytopenia is defined as a platelet count between 0.3 and 0.6 × 10⁶/μl, whereas severe thrombocytopenia is defined as less than 0.3 × 10⁶/μl.

†

ND, not determined, as mice died of shock before platelet count could be obtained.

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