Effects of SB on the expression of CD80, CD86, HLA-DR, HLA-ABC, and ICAM-1 in clinical AML samples
| UPN . | FAB subtype . | Karyotype . | CD80 . | CD86 . | HLA-DR . | ICAM-1 . | HLA-ABC . |
|---|---|---|---|---|---|---|---|
| 8614 | M0 | normal | 1.06 | 1.32 | 3.20 | 1.30 | 0.83 |
| 8002 | M1 | normal | 1.07 | 1.68 | 2.01 | 0.83 | 1.05 |
| 8139 | M1 | 43,XX,t(3;9)(q26;p22),-5,-6,-7 | 0.85 | 1.11 | 1.04 | 1.19 | 1.06 |
| 8589 | M1 | normal | 1.05 | 1.84 | 1.29 | 0.89 | 1.19 |
| 7821 | M2 | 46,XY,t(8;21)(q22;q22) | 1.36 | 1.90 | 1.28 | 1.63 | 0.92 |
| 7990 | M2 | 45,X,-Y,t(8;21)(q22;q22) | 1.01 | 1.27 | 1.03 | 1.07 | 3.34 |
| 8133 | M2 | normal | 1.17 | 3.85 | 1.27 | 1.24 | 1.20 |
| 8281 | M2 | 46,XY,t(8;21)(q22;q22) | 0.93 | 0.93 | 0.92 | 1.00 | 0.96 |
| 8332 | M2 | normal | 0.90 | 1.22 | 1.25 | 1.08 | 1.14 |
| 8437 | M2 | 46,XY,t(8;21)(q22;q22) | 0.73 | 1.04 | 0.91 | 1.12 | 1.08 |
| 8576 | M2 | 46,XY,t(10;11)(p13;q14) | 1.02 | 3.70 | 0.73 | 0.92 | 0.78 |
| 8580 | M2 | 46,XY,t(8;21)(q22;q22) | 1.23 | 1.19 | 0.95 | 1.28 | 1.00 |
| 8581 | M2 | 46,XY,t(8;21)(q22;q22) | 1.06 | 1.09 | 1.92 | 1.08 | 0.99 |
| 8583 | M2 | 45,X,-Y,t(8;21)(q22;q22) | 1.06 | 1.56 | 1.51 | 1.18 | 0.72 |
| 8588 | M2 | normal | 1.04 | 1.96 | 0.95 | 1.62 | 0.81 |
| 8616 | M2 | 46,XX,-9+mar1 | 1.02 | 0.88 | 2.28 | 1.60 | 0.89 |
| 8625 | M2 | ND | 0.88 | 1.86 | 1.43 | 1.15 | 0.98 |
| 8646 | M2 | 46,XY,del(1)(p13p22),add(17)(p11) | 1.08 | 3.06 | 2.03 | 1.20 | 0.80 |
| 8647 | M2 | 47,XX,+5 | 1.06 | 0.84 | 0.57 | 0.78 | 1.00 |
| 8622 | M3 | 46,XY,t(15;17)(q22;q21) | 0.97 | 1.02 | 1.26 | 0.94 | 0.94 |
| 7873 | M4 | 46,XX,t(1;5)(q21;q32) | 0.53 | 1.19 | 0.94 | 0.55 | 1.09 |
| 8000 | M4 | 46,XY,t(6;11)(q27;q23) | 0.64 | 1.45 | 1.34 | 0.87 | 0.89 |
| 8543 | M4 | 46,XY,i(17)(q10) | 0.77 | 0.62 | 1.16 | 0.97 | 0.72 |
| 8598 | M4 | normal | 1.84 | 3.86 | 1.28 | 2.15 | 1.69 |
| 8611 | M4 | 47,xx,+del(5)(q?),-8,del(17)(p11),+18,2∼52dmin | 0.70 | 1.01 | 1.02 | 0.76 | 1.01 |
| 8645 | M4 | normal | 1.04 | 2.08 | 0.48 | 1.20 | 0.75 |
| 8638 | M5a | 48,XX,+8,inv(9)(p11q13),inv(16)(p13q22) | 0.89 | 0.96 | 0.96 | 1.50 | 0.99 |
| 8354 | M5a | 47,XY,+6 | 0.82 | 0.87 | 1.13 | 1.10 | 0.94 |
| 7844 | M5b | 46,XX,t(1;5)(q21;q32) | 0.85 | 1.33 | 1.02 | 0.97 | 1.05 |
| 8308 | M6 | 46,XX,del(9)(q11-13q22) | 1.33 | 2.34 | 0.80 | 1.26 | 0.92 |
| UPN . | FAB subtype . | Karyotype . | CD80 . | CD86 . | HLA-DR . | ICAM-1 . | HLA-ABC . |
|---|---|---|---|---|---|---|---|
| 8614 | M0 | normal | 1.06 | 1.32 | 3.20 | 1.30 | 0.83 |
| 8002 | M1 | normal | 1.07 | 1.68 | 2.01 | 0.83 | 1.05 |
| 8139 | M1 | 43,XX,t(3;9)(q26;p22),-5,-6,-7 | 0.85 | 1.11 | 1.04 | 1.19 | 1.06 |
| 8589 | M1 | normal | 1.05 | 1.84 | 1.29 | 0.89 | 1.19 |
| 7821 | M2 | 46,XY,t(8;21)(q22;q22) | 1.36 | 1.90 | 1.28 | 1.63 | 0.92 |
| 7990 | M2 | 45,X,-Y,t(8;21)(q22;q22) | 1.01 | 1.27 | 1.03 | 1.07 | 3.34 |
| 8133 | M2 | normal | 1.17 | 3.85 | 1.27 | 1.24 | 1.20 |
| 8281 | M2 | 46,XY,t(8;21)(q22;q22) | 0.93 | 0.93 | 0.92 | 1.00 | 0.96 |
| 8332 | M2 | normal | 0.90 | 1.22 | 1.25 | 1.08 | 1.14 |
| 8437 | M2 | 46,XY,t(8;21)(q22;q22) | 0.73 | 1.04 | 0.91 | 1.12 | 1.08 |
| 8576 | M2 | 46,XY,t(10;11)(p13;q14) | 1.02 | 3.70 | 0.73 | 0.92 | 0.78 |
| 8580 | M2 | 46,XY,t(8;21)(q22;q22) | 1.23 | 1.19 | 0.95 | 1.28 | 1.00 |
| 8581 | M2 | 46,XY,t(8;21)(q22;q22) | 1.06 | 1.09 | 1.92 | 1.08 | 0.99 |
| 8583 | M2 | 45,X,-Y,t(8;21)(q22;q22) | 1.06 | 1.56 | 1.51 | 1.18 | 0.72 |
| 8588 | M2 | normal | 1.04 | 1.96 | 0.95 | 1.62 | 0.81 |
| 8616 | M2 | 46,XX,-9+mar1 | 1.02 | 0.88 | 2.28 | 1.60 | 0.89 |
| 8625 | M2 | ND | 0.88 | 1.86 | 1.43 | 1.15 | 0.98 |
| 8646 | M2 | 46,XY,del(1)(p13p22),add(17)(p11) | 1.08 | 3.06 | 2.03 | 1.20 | 0.80 |
| 8647 | M2 | 47,XX,+5 | 1.06 | 0.84 | 0.57 | 0.78 | 1.00 |
| 8622 | M3 | 46,XY,t(15;17)(q22;q21) | 0.97 | 1.02 | 1.26 | 0.94 | 0.94 |
| 7873 | M4 | 46,XX,t(1;5)(q21;q32) | 0.53 | 1.19 | 0.94 | 0.55 | 1.09 |
| 8000 | M4 | 46,XY,t(6;11)(q27;q23) | 0.64 | 1.45 | 1.34 | 0.87 | 0.89 |
| 8543 | M4 | 46,XY,i(17)(q10) | 0.77 | 0.62 | 1.16 | 0.97 | 0.72 |
| 8598 | M4 | normal | 1.84 | 3.86 | 1.28 | 2.15 | 1.69 |
| 8611 | M4 | 47,xx,+del(5)(q?),-8,del(17)(p11),+18,2∼52dmin | 0.70 | 1.01 | 1.02 | 0.76 | 1.01 |
| 8645 | M4 | normal | 1.04 | 2.08 | 0.48 | 1.20 | 0.75 |
| 8638 | M5a | 48,XX,+8,inv(9)(p11q13),inv(16)(p13q22) | 0.89 | 0.96 | 0.96 | 1.50 | 0.99 |
| 8354 | M5a | 47,XY,+6 | 0.82 | 0.87 | 1.13 | 1.10 | 0.94 |
| 7844 | M5b | 46,XX,t(1;5)(q21;q32) | 0.85 | 1.33 | 1.02 | 0.97 | 1.05 |
| 8308 | M6 | 46,XX,del(9)(q11-13q22) | 1.33 | 2.34 | 0.80 | 1.26 | 0.92 |
Cells were incubated in the presence or absence of 1.0 mmol/L SB for 48 hours. The MFIs of CD80, CD86, HLA-DR, HLA-ABC, and ICAM-1 were analyzed by flow cytometry. The fold induction of the intensity of expression derived from SB-treated cells relative to that from medium-treated cells is presented. ND indicates karyotyping not done.