Proportion of somatic abnormalities in Fanconi anemia complementation groups
| N = . | Complementation groups . | A/C/G . | Comparisons* . | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All . | A . | B . | C . | D . | E . | F . | G . | A/C . | A/G . | C/G . | ||||||
| 246 . | 172 . | 1 . | 34 . | 3 . | 5 . | 6 . | 24 . | . | . | . | . | |||||
| . | N . | % . | N . | % . | N . | N . | % . | N . | N . | N . | N . | % . | . | Pvalue . | P value . | P value . |
| Skin | 166/235 | 71 | 124/167 | 74 | 1/1 | 15/30 | 50 | 3/3 | 3/5 | 3/6 | 16/24 | 66 | .0448 | .0250 | .4600 | .4000 |
| Growth retardation | 135/233 | 58 | 98/164 | 60 | 1/1 | 8/30 | 28 | 2/3 | 4/5 | 4/6 | 18/24 | 75 | .0009 | .0020 | .1800 | .0007 |
| Head | 132/237 | 56 | 97/170 | 53 | 1/1 | 7/31 | 23 | 3/3 | 5/5 | 2/6 | 17/22 | 77 | .0002 | .0007 | .1000 | .0002 |
| Radial ray | 115/243 | 47 | 83/170 | 49 | 1/1 | 6/34 | 18 | 3/3 | 5/5 | 4/6 | 13/24 | 54 | .0033 | .0010 | .6700 | .0090 |
| Kidneys | 53/243 | 22 | 33/170 | 19 | 0/1 | 8/34 | 24 | 1/3 | 4/5 | 2/6 | 4/24 | 17 | .7505 | — | — | — |
| Skeleton | 44/243 | 18 | 28/170 | 16 | 1/1 | 4/34 | 12 | 2/3 | 4/5 | 2/6 | 3/24 | 13 | .7497 | — | — | — |
| Urogenital tract | 29/243 | 12 | 22/170 | 13 | 1/1 | 0/34 | 0 | 2/3 | 3/5 | 1/6 | 1/24 | 4.2 | .0466 | .0300 | .3100 | .4200 |
| Gastrointestinal tract | 31/243 | 13 | 17/170 | 10 | 1/1 | 5/33 | 15 | 1/3 | 2/5 | 3/6 | 3/24 | 13 | .3957 | — | — | — |
| Mental retardation | 28/237 | 12 | 20/170 | 12 | 0/1 | 1/29 | 3.4 | 1/3 | 2/4 | 2/5 | 2/24 | 8.3 | .3741 | — | — | — |
| Heart | 25/243 | 10 | 16/170 | 9.4 | 0/1 | 2/34 | 6.1 | 3/3 | 0/5 | 2/6 | 1/24 | 4.2 | .5996 | — | — | — |
| Deafness | 22/237 | 9.3 | 19/159 | 11 | 0/1 | 0/29 | 0 | 1/3 | 0/4 | 1/5 | 1/24 | 4.2 | .1028 | — | — | — |
| Central nervous system | 11/243 | 4.5 | 4/170 | 2.4 | 0/1 | 4/34 | 12 | 0/3 | 3/5 | 0/6 | 0/24 | 0 | .0104 | .0080 | > .99 | .1300 |
| Mean number of abnormalities | 3.3 | 3.3 | 6 | 1.9 | 7.6 | 7.6 | 4.5 | 3.5 | < .0001 | < .0001 | .7800 | .0020 | ||||
| Mean number of sites | 1.8 | 1.8 | 3 | 1.1 | 4.3 | 4.6 | 3.2 | 1.9 | .0146 | .0060 | .6500 | .0400 | ||||
| N = . | Complementation groups . | A/C/G . | Comparisons* . | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All . | A . | B . | C . | D . | E . | F . | G . | A/C . | A/G . | C/G . | ||||||
| 246 . | 172 . | 1 . | 34 . | 3 . | 5 . | 6 . | 24 . | . | . | . | . | |||||
| . | N . | % . | N . | % . | N . | N . | % . | N . | N . | N . | N . | % . | . | Pvalue . | P value . | P value . |
| Skin | 166/235 | 71 | 124/167 | 74 | 1/1 | 15/30 | 50 | 3/3 | 3/5 | 3/6 | 16/24 | 66 | .0448 | .0250 | .4600 | .4000 |
| Growth retardation | 135/233 | 58 | 98/164 | 60 | 1/1 | 8/30 | 28 | 2/3 | 4/5 | 4/6 | 18/24 | 75 | .0009 | .0020 | .1800 | .0007 |
| Head | 132/237 | 56 | 97/170 | 53 | 1/1 | 7/31 | 23 | 3/3 | 5/5 | 2/6 | 17/22 | 77 | .0002 | .0007 | .1000 | .0002 |
| Radial ray | 115/243 | 47 | 83/170 | 49 | 1/1 | 6/34 | 18 | 3/3 | 5/5 | 4/6 | 13/24 | 54 | .0033 | .0010 | .6700 | .0090 |
| Kidneys | 53/243 | 22 | 33/170 | 19 | 0/1 | 8/34 | 24 | 1/3 | 4/5 | 2/6 | 4/24 | 17 | .7505 | — | — | — |
| Skeleton | 44/243 | 18 | 28/170 | 16 | 1/1 | 4/34 | 12 | 2/3 | 4/5 | 2/6 | 3/24 | 13 | .7497 | — | — | — |
| Urogenital tract | 29/243 | 12 | 22/170 | 13 | 1/1 | 0/34 | 0 | 2/3 | 3/5 | 1/6 | 1/24 | 4.2 | .0466 | .0300 | .3100 | .4200 |
| Gastrointestinal tract | 31/243 | 13 | 17/170 | 10 | 1/1 | 5/33 | 15 | 1/3 | 2/5 | 3/6 | 3/24 | 13 | .3957 | — | — | — |
| Mental retardation | 28/237 | 12 | 20/170 | 12 | 0/1 | 1/29 | 3.4 | 1/3 | 2/4 | 2/5 | 2/24 | 8.3 | .3741 | — | — | — |
| Heart | 25/243 | 10 | 16/170 | 9.4 | 0/1 | 2/34 | 6.1 | 3/3 | 0/5 | 2/6 | 1/24 | 4.2 | .5996 | — | — | — |
| Deafness | 22/237 | 9.3 | 19/159 | 11 | 0/1 | 0/29 | 0 | 1/3 | 0/4 | 1/5 | 1/24 | 4.2 | .1028 | — | — | — |
| Central nervous system | 11/243 | 4.5 | 4/170 | 2.4 | 0/1 | 4/34 | 12 | 0/3 | 3/5 | 0/6 | 0/24 | 0 | .0104 | .0080 | > .99 | .1300 |
| Mean number of abnormalities | 3.3 | 3.3 | 6 | 1.9 | 7.6 | 7.6 | 4.5 | 3.5 | < .0001 | < .0001 | .7800 | .0020 | ||||
| Mean number of sites | 1.8 | 1.8 | 3 | 1.1 | 4.3 | 4.6 | 3.2 | 1.9 | .0146 | .0060 | .6500 | .0400 | ||||
FA indicates Fanconi anemia.
Significant P values are shown in bold. The prevalence of abnormalities was lower in FA-C than in FA-A or FA-G in all cases with the exception of the central nervous system.