Causes of death after day 100 after bone marrow transplantation, according to time to platelet recovery
| Cause of death . | Platelet level recovered by day 30 . | Platelet level recovered by day 31-100 . | Platelet level not recovered by day 100 . | P value . |
|---|---|---|---|---|
| Recurrent or residual leukemia | 142 (39) | 156 (39) | 124 (21) | <.0001 |
| Acute or chronic GVHD | 39 (11) | 45 (11) | 88 (15) | NS |
| Bacterial infection | 22 (6) | 22 (6) | 36 (6) | NS |
| ARDS | 24 (7) | 18 (5) | 38 (7) | NS |
| Fungal infection | 23 (6) | 33 (8) | 71 (12) | NS |
| Other pneumonia | 21 (6) | 24 (6) | 49 (8) | NS |
| Secondary malignancy | 7 (2) | 5 (1) | 4 (1) | NS |
| CMV pneumonia | 9 (3) | 4 (1) | 19 (3) | NS |
| Hemorrhage | 10 (3) | 10 (3) | 25 (4) | NS |
| Graft failure | 2 (1) | 3 (1) | 6 (1) | NS |
| Other | 62 (17) | 77 (19) | 128 (22) | NS |
| Cause of death . | Platelet level recovered by day 30 . | Platelet level recovered by day 31-100 . | Platelet level not recovered by day 100 . | P value . |
|---|---|---|---|---|
| Recurrent or residual leukemia | 142 (39) | 156 (39) | 124 (21) | <.0001 |
| Acute or chronic GVHD | 39 (11) | 45 (11) | 88 (15) | NS |
| Bacterial infection | 22 (6) | 22 (6) | 36 (6) | NS |
| ARDS | 24 (7) | 18 (5) | 38 (7) | NS |
| Fungal infection | 23 (6) | 33 (8) | 71 (12) | NS |
| Other pneumonia | 21 (6) | 24 (6) | 49 (8) | NS |
| Secondary malignancy | 7 (2) | 5 (1) | 4 (1) | NS |
| CMV pneumonia | 9 (3) | 4 (1) | 19 (3) | NS |
| Hemorrhage | 10 (3) | 10 (3) | 25 (4) | NS |
| Graft failure | 2 (1) | 3 (1) | 6 (1) | NS |
| Other | 62 (17) | 77 (19) | 128 (22) | NS |
Unless otherwise indicated, values are number of patients and, in parentheses, frequency expressed as a percentage of those in that category who have died. The total numbers of patients in each category who have died are 361 in the group with recovery of platelet levels at day 30, 397 in the group with recovery between day 31 and day 100, and 588 in the group without recovery at day 100.
NS indicates not significant; GVHD, graft-versus-host disease; ARDS, adult respiratory distress syndrome; CMV, cytomegalovirus.