CXB-12 mice have normal numbers of peripheral blood cells, bone marrow cells, and colony-forming unit spleen
| Parameter . | B6 . | BALB . | CByB6F1 . | CXB-12 . |
|---|---|---|---|---|
| In peripheral blood | ||||
| WBC (109/L) | 15.0 ± 0.9 | 10.7 ± 1.9 | 11.9 ± 2.4 | 10.2 ± 2.3 |
| RBC (109/mL) | 1.12 ± 0.31 | 1.38 ± 0.33 | 1.51 ± 0.41 | 1.43 ± 0.28 |
| B220 (%) | 54.6 ± 4.5 | 20.5 ± 1.9 | 30.3 ± 2.1 | 32.5 ± 3.7 |
| CD4 (%) | 11.5 ± 0.1 | 29.4 ± 3.5 | 32.0 ± 1.0 | 20.1 ± 1.3 |
| CD8 (%) | 12.0 ± 0.3 | 14.8 ± 0.9 | 16.0 ± 0.1 | 14.3 ± 1.3 |
| In bone marrow | ||||
| Total BMC (105) | 3040 ± 288 | 2163 ± 32 | 2528 ± 87 | 3043 ± 149 |
| B220 (%) | 27.7 ± 0.1 | 28.1 ± 1.1 | 23.1 ± 1.3 | 24.3 ± 0.2 |
| CD4 (%) | 0.84 ± 0.07 | 0.78 ± 0.06 | 0.72 ± 0.07 | 0.74 ± 0.08 |
| CD8 (%) | 1.53 ± 0.05 | 0.66 ± 0.05 | 0.82 ± 0.10 | 0.53 ± 0.11 |
| CFU-S, day 12 | 8.8 ± 0.8 | 9.5 ± 1.0 | 9.0 ± 1.5 | 10.0 ± 0.6 |
| Pre–CFU-S, day 7 | 2.5 ± 1.2 | 3.7 ± 1.2 | 2.4 ± 1.0 | 1.0 ± 0.3 |
| Pre–CFU-S, day 14 | 3.0 ± 0.6 | 3.0 ± 0.5 | 1.0 ± 0.5 | 1.6 ± 0.4 |
| Parameter . | B6 . | BALB . | CByB6F1 . | CXB-12 . |
|---|---|---|---|---|
| In peripheral blood | ||||
| WBC (109/L) | 15.0 ± 0.9 | 10.7 ± 1.9 | 11.9 ± 2.4 | 10.2 ± 2.3 |
| RBC (109/mL) | 1.12 ± 0.31 | 1.38 ± 0.33 | 1.51 ± 0.41 | 1.43 ± 0.28 |
| B220 (%) | 54.6 ± 4.5 | 20.5 ± 1.9 | 30.3 ± 2.1 | 32.5 ± 3.7 |
| CD4 (%) | 11.5 ± 0.1 | 29.4 ± 3.5 | 32.0 ± 1.0 | 20.1 ± 1.3 |
| CD8 (%) | 12.0 ± 0.3 | 14.8 ± 0.9 | 16.0 ± 0.1 | 14.3 ± 1.3 |
| In bone marrow | ||||
| Total BMC (105) | 3040 ± 288 | 2163 ± 32 | 2528 ± 87 | 3043 ± 149 |
| B220 (%) | 27.7 ± 0.1 | 28.1 ± 1.1 | 23.1 ± 1.3 | 24.3 ± 0.2 |
| CD4 (%) | 0.84 ± 0.07 | 0.78 ± 0.06 | 0.72 ± 0.07 | 0.74 ± 0.08 |
| CD8 (%) | 1.53 ± 0.05 | 0.66 ± 0.05 | 0.82 ± 0.10 | 0.53 ± 0.11 |
| CFU-S, day 12 | 8.8 ± 0.8 | 9.5 ± 1.0 | 9.0 ± 1.5 | 10.0 ± 0.6 |
| Pre–CFU-S, day 7 | 2.5 ± 1.2 | 3.7 ± 1.2 | 2.4 ± 1.0 | 1.0 ± 0.3 |
| Pre–CFU-S, day 14 | 3.0 ± 0.6 | 3.0 ± 0.5 | 1.0 ± 0.5 | 1.6 ± 0.4 |
WBC indicates white blood cell; RBC, red blood cell; BMC, bone marrow cell; CFU-S, colony-forming unit spleen.
Data given as mean ± SEM after variance analysis; N = 3–8. Pre–CFU-S were retransplanted to give numbers of 12 day CFU-S in CByB6F1 recipients of 4 × 105 BMCs from CByB6F1 carriers given 106 BMCs 7 days earlier or 2 × 105 BMCs 14 days earlier.