Immunophenotipic analyses (percentages of cells) in 3 groups of older children (mean age = 7 years)
| Marker . | SR (n = 41) . | UC (n = 15) . | HIV+ (n = 25) . | Statistical significance (P value) . | ||
|---|---|---|---|---|---|---|
| SR vs UC . | SR vs HIV+ . | UC vs HIV+ . | ||||
| CD4 | 38.4 ± 6.8 | 40.4 ± 4.6 | 28.2 ± 9.9 | ns | .0004 | < .0001 |
| CD8 | 24.2 ± 5.3 | 25.6 ± 3.7 | 42.9 ± 11.1 | ns | < .0001 | .0001 |
| CD4/CD8 ratio | 1.7 ± 0.7 | 1.6 ± 0.3 | 0.8 ± 0.5 | ns | < .0001 | < .0001 |
| CD4/RA/62 | 62.9 ± 9.8 | 71.8 ± 8.6 | 57.9 ± 9.6 | .03 | ns | .001 |
| CD4/RO | 37.1 ± 10.1 | 29.1 ± 8.6 | 42.3 ± 14.2 | .001 | ns | .001 |
| CD8/RA/LFAlow | 40.7 ± 8.5 | 48.9 ± 4.2 | 22.7 ± 4.1 | ns | .0001 | < .0001 |
| CD8/RA/LFAhigh | 25.3 ± 2.2 | 26.6 ± 4.7 | 28.2 ± 3.5 | ns | ns | ns |
| CD8/38dim | 34 ± 13.7 | 48.7 ± 6.2 | 47.5 ± 13.6 | .004 | .003 | ns |
| CD8/38bright | 15.5 ± 5.6 | 5.6 ± 1.4 | 25.4 ± 8.1 | .01 | .009 | .001 |
| CD3 DN | 9.3 ± 2.2 | 6.5 ± 2.3 | 11.9 ± 4.9 | .02 | ns | .002 |
| CD3 DN/44 | 8.4 ± 2.7 | 5.1 ± 3.7 | 11.5 ± 5.1 | .001 | ns | .001 |
| Marker . | SR (n = 41) . | UC (n = 15) . | HIV+ (n = 25) . | Statistical significance (P value) . | ||
|---|---|---|---|---|---|---|
| SR vs UC . | SR vs HIV+ . | UC vs HIV+ . | ||||
| CD4 | 38.4 ± 6.8 | 40.4 ± 4.6 | 28.2 ± 9.9 | ns | .0004 | < .0001 |
| CD8 | 24.2 ± 5.3 | 25.6 ± 3.7 | 42.9 ± 11.1 | ns | < .0001 | .0001 |
| CD4/CD8 ratio | 1.7 ± 0.7 | 1.6 ± 0.3 | 0.8 ± 0.5 | ns | < .0001 | < .0001 |
| CD4/RA/62 | 62.9 ± 9.8 | 71.8 ± 8.6 | 57.9 ± 9.6 | .03 | ns | .001 |
| CD4/RO | 37.1 ± 10.1 | 29.1 ± 8.6 | 42.3 ± 14.2 | .001 | ns | .001 |
| CD8/RA/LFAlow | 40.7 ± 8.5 | 48.9 ± 4.2 | 22.7 ± 4.1 | ns | .0001 | < .0001 |
| CD8/RA/LFAhigh | 25.3 ± 2.2 | 26.6 ± 4.7 | 28.2 ± 3.5 | ns | ns | ns |
| CD8/38dim | 34 ± 13.7 | 48.7 ± 6.2 | 47.5 ± 13.6 | .004 | .003 | ns |
| CD8/38bright | 15.5 ± 5.6 | 5.6 ± 1.4 | 25.4 ± 8.1 | .01 | .009 | .001 |
| CD3 DN | 9.3 ± 2.2 | 6.5 ± 2.3 | 11.9 ± 4.9 | .02 | ns | .002 |
| CD3 DN/44 | 8.4 ± 2.7 | 5.1 ± 3.7 | 11.5 ± 5.1 | .001 | ns | .001 |
SR = healthy HIV-uninfected children of HIV-infected mothers (seroreverters); UC = healthy children of HIV-negative women (uninfected controls); HIV+ = HIV-infected children; ns = statistically not significant; DN = double negatives; LFA = leukocyte function-associated antigen.
Mean values ± standard deviations are shown.