Table 1. Body weight (BW), systolic... | American Society of Hematology

Table 1.

Body weight (BW), systolic blood pressure (SBP), heart rate (HR), and total plasma cholesterol and triglyceride levels in C57Bl/6, apoE^−/−, and LDLR^−/− mice (n = 14 for each group)

	Age (wk)	C57Bl/6 chow	ApoE^−/−chow	LDLR^−/− chow	LDLR^−/− Western diet
BW (g)	6	22 ± 2	21 ± 1.7	21 ± 2.1	21 ± 2.1
	26	32 ± 2^*	36 ± 4.1^*	37.5 ± 3^*	37.5 ± 3^*
SBP (mm Hg)	6	115 ± 12	121 ± 10	122 ± 14	116 ± 13
	26	118 ± 16	140 ± 12^*	118 ± 12	148 ± 14^*
HR (bpm)	6	558 ± 30	575 ± 22	580 ± 30	572 ± 24
	26	610 ± 28	603 ± 25	620 ± 21	615 ± 25
Cholesterol (mg/dL)	6	130 ± 15	450 ± 22	190 ± 20	200 ± 16
	16	135 ± 20	600 ± 25^*	210 ± 22	1200 ± 25^†
	26	150 ± 18	800 ± 35^*	240 ± 18	1770 ± 45^†
Triglycerides (mg/dL)	6	70 ± 10	80 ± 6	85 ± 12	95 ± 10
	26	90 ± 10	95 ± 11	90 ± 8	930 ± 40^†

	Age (wk)	C57Bl/6 chow	ApoE^−/−chow	LDLR^−/− chow	LDLR^−/− Western diet
BW (g)	6	22 ± 2	21 ± 1.7	21 ± 2.1	21 ± 2.1
	26	32 ± 2^*	36 ± 4.1^*	37.5 ± 3^*	37.5 ± 3^*
SBP (mm Hg)	6	115 ± 12	121 ± 10	122 ± 14	116 ± 13
	26	118 ± 16	140 ± 12^*	118 ± 12	148 ± 14^*
HR (bpm)	6	558 ± 30	575 ± 22	580 ± 30	572 ± 24
	26	610 ± 28	603 ± 25	620 ± 21	615 ± 25
Cholesterol (mg/dL)	6	130 ± 15	450 ± 22	190 ± 20	200 ± 16
	16	135 ± 20	600 ± 25^*	210 ± 22	1200 ± 25^†
	26	150 ± 18	800 ± 35^*	240 ± 18	1770 ± 45^†
Triglycerides (mg/dL)	6	70 ± 10	80 ± 6	85 ± 12	95 ± 10
	26	90 ± 10	95 ± 11	90 ± 8	930 ± 40^†

Data are expressed as mean ± SEM

P < .001 versus 6 weeks;

†

P < .0001 versus 6 weeks.

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