Variations in median CD34+ cell apoptosis, proliferation, and Bcl-2–related protein ratios according to karyotype
| Characteristic . | Good risk (range) . | Intermediate risk (range) . | Poor risk (range) . | P . | Chromosome 7 abnormalities (range) . | P . |
|---|---|---|---|---|---|---|
| Apoptosis (%) | 55.1 (2.1-93.6) | 46.1 (9.9-83.8) | 25.9 (3-86.5) | .02 | 23.4 (3-56.9) | .0007 |
| Proliferation (%) | 27.6 (4-75.8) | 24.9 (8-38.5) | 28.6 (1.9-69.5) | N/S | 23.6 (1.9-52.6) | N/S |
| A:P ratio | 1.79 (0.16-5.7) | 1.91 (1.37-3.4) | 1.54 (0.8-12.2) | N/S | 1.79 (0.85-5.67) | N/S |
| Bax/Bad:Bcl-2/Bcl-X ratio | 2.36 (1.17-9.42) | 1.14 (0.06-5.77) | 1.17 (0.4-2.89) | .03 | 1.17 (0.4-2.89) | .08 |
| Characteristic . | Good risk (range) . | Intermediate risk (range) . | Poor risk (range) . | P . | Chromosome 7 abnormalities (range) . | P . |
|---|---|---|---|---|---|---|
| Apoptosis (%) | 55.1 (2.1-93.6) | 46.1 (9.9-83.8) | 25.9 (3-86.5) | .02 | 23.4 (3-56.9) | .0007 |
| Proliferation (%) | 27.6 (4-75.8) | 24.9 (8-38.5) | 28.6 (1.9-69.5) | N/S | 23.6 (1.9-52.6) | N/S |
| A:P ratio | 1.79 (0.16-5.7) | 1.91 (1.37-3.4) | 1.54 (0.8-12.2) | N/S | 1.79 (0.85-5.67) | N/S |
| Bax/Bad:Bcl-2/Bcl-X ratio | 2.36 (1.17-9.42) | 1.14 (0.06-5.77) | 1.17 (0.4-2.89) | .03 | 1.17 (0.4-2.89) | .08 |
A:P indicates apopotosis:proliferation ratio; N/S, not significant.