Median levels of apoptosis, proliferation, apoptosis:proliferation (A:P) ratio and Bax/Bad:Bcl2/BclX ratio in different diagnostic subgroups
| Disease subgroup . | Apoptosis (%) (range) . | Proliferation (%) (range) . | A:P ratio (range) . | Bax/Bad:Bcl-2/ Bcl-X ratio (range) . |
|---|---|---|---|---|
| NBM | 16.7 (3.4-35.3) | 18.7 (5.1-59.6) | 0.81 (0.48-1.6) | 1.89 (0.65-4.12) |
| RA/RARS | 56.9 (20.4-93.6) | 26.1 (9.5-47.8) | 2.08 (1.15-3.63) | 2.57 (1.93-9.42) |
| RAEB | 51.2 (25.2-76.6) | 40.4 (22-69.5) | 1.14 (0.93-2.06) | 1.19 (1.14-2.08) |
| RAEB-t/MDS-AML | 22.3 (2.1-53.2) | 16.85 (1.9-75.8) | 1.69 (0.16-12.2) | 0.85 (0.06-3.32) |
| Disease subgroup . | Apoptosis (%) (range) . | Proliferation (%) (range) . | A:P ratio (range) . | Bax/Bad:Bcl-2/ Bcl-X ratio (range) . |
|---|---|---|---|---|
| NBM | 16.7 (3.4-35.3) | 18.7 (5.1-59.6) | 0.81 (0.48-1.6) | 1.89 (0.65-4.12) |
| RA/RARS | 56.9 (20.4-93.6) | 26.1 (9.5-47.8) | 2.08 (1.15-3.63) | 2.57 (1.93-9.42) |
| RAEB | 51.2 (25.2-76.6) | 40.4 (22-69.5) | 1.14 (0.93-2.06) | 1.19 (1.14-2.08) |
| RAEB-t/MDS-AML | 22.3 (2.1-53.2) | 16.85 (1.9-75.8) | 1.69 (0.16-12.2) | 0.85 (0.06-3.32) |
NBM indicates normal donors; RA, refractory anemia; RARS, RA with ringed sideroblasts; RAEB, RA with excess blasts; RAEB-t, RAEB in transformation; MDS-AML, acute myeloid leukemia secondary to myelodysplastic syndrome.