Effect of all-trans retinoic acid on folate receptor expression in various cell lines
| Cell line . | Cell type* . | FR expression† . | ||
|---|---|---|---|---|
| Before treatment . | After treatment . | |||
| FR-α . | FR-β . | |||
| KG-1 | Acute myelogenous leukemia | — | 0.02 ± 0.01 | 0.5 ± 0.1 |
| KG-1a | Acute myelogenous leukemia | — | — | — |
| NB4 | Acute promyelocytic leukemia | — | — | — |
| HL60 | Acute promyelocytic leukemia | — | — | — |
| KCL22 | Myeloblastic leukemia | — | — | — |
| K562 | Erythroleukemia | — | — | — |
| CCFR-CEM | Acute lymphoblastic leukemia | — | — | — |
| L1210 | Mouse lymphoblastic leukemia | — | — | — |
| SVG | Transformed fibroblast | — | — | — |
| MG-63 | Osteosarcoma | — | — | — |
| 293 | Transformed primary embryonal kidney epithelial cell | — | — | — |
| SKOV3 | Ovarian adenocarcinoma | 0.25 ± 0.02 | — | 0.26 ± 0.03 |
| JAR | Placental choriocarcinoma | 1.50 ± 0.20 | — | 1.10 ± 0.10 |
| HeLa | Cervical carcinoma | 1.70 ± 0.20 | — | 1.20 ± 0.20 |
| Caki-1 | Kidney carcinoma | — | — | — |
| Cell line . | Cell type* . | FR expression† . | ||
|---|---|---|---|---|
| Before treatment . | After treatment . | |||
| FR-α . | FR-β . | |||
| KG-1 | Acute myelogenous leukemia | — | 0.02 ± 0.01 | 0.5 ± 0.1 |
| KG-1a | Acute myelogenous leukemia | — | — | — |
| NB4 | Acute promyelocytic leukemia | — | — | — |
| HL60 | Acute promyelocytic leukemia | — | — | — |
| KCL22 | Myeloblastic leukemia | — | — | — |
| K562 | Erythroleukemia | — | — | — |
| CCFR-CEM | Acute lymphoblastic leukemia | — | — | — |
| L1210 | Mouse lymphoblastic leukemia | — | — | — |
| SVG | Transformed fibroblast | — | — | — |
| MG-63 | Osteosarcoma | — | — | — |
| 293 | Transformed primary embryonal kidney epithelial cell | — | — | — |
| SKOV3 | Ovarian adenocarcinoma | 0.25 ± 0.02 | — | 0.26 ± 0.03 |
| JAR | Placental choriocarcinoma | 1.50 ± 0.20 | — | 1.10 ± 0.10 |
| HeLa | Cervical carcinoma | 1.70 ± 0.20 | — | 1.20 ± 0.20 |
| Caki-1 | Kidney carcinoma | — | — | — |
FR indicates folate receptor. FR expression was detected by [3H] folic acid binding, immunoblotting with the use of antibody to FR-α or FR-β, and Northern blot by means of complementary DNA probes specific for FR-α or FR-β.
The cell lines are of human origin unless indicated otherwise.
Expressed as picomoles per 106 cells; a dash indicates that FR expression was undetectable.