Prognostic factors affecting overall survival
| Variables . | Unfavorable factors . | Univariate . | Multivariate5-150 . | ||
|---|---|---|---|---|---|
| Hazard ratio (CI) . | P value . | Hazard ratio (CI) . | P value . | ||
| Comparison with risk factors | |||||
| Age | > 60 years | 3.1 (1.7-5.7) | .0003 | 4.1 (2.1-7.8) | .00003 |
| CD56 | Positive | 2.7 (1.4-5.1) | .003 | 3.1 (1.5-6.1) | .001 |
| Stage | III/IV | 2.4 (1.2-4.8) | .01 | 2.8 (1.3-6.1) | .008 |
| PS | 2-4 | 3.4 (1.9-6.1) | .00003 | 2.5 (1.4-4.6) | .003 |
| EBV | Positive | 3.2 (1.6-6.7) | .002 | — | |
| ALK | Negative | 2.5 (1.4-4.9) | .001 | — | |
| B symptom | Present | 2.1 (1.1-3.7) | .01 | — | |
| Extranodal disease | ≧ 2 sites | 1.9 (1.1-3.5) | .03 | — | |
| LDH | > normal | 1.8 (1.0-3.1) | .05 | — | |
| Comparison with IPI category | |||||
| IPI category | H-I/H | 4.1 (2.2-7.3) | .000004 | 4.0 (2.2-7.2) | .00001 |
| CD56 | Positive | 2.7 (1.4-5.1) | .003 | 2.6 (1.3-5.0) | .004 |
| Variables . | Unfavorable factors . | Univariate . | Multivariate5-150 . | ||
|---|---|---|---|---|---|
| Hazard ratio (CI) . | P value . | Hazard ratio (CI) . | P value . | ||
| Comparison with risk factors | |||||
| Age | > 60 years | 3.1 (1.7-5.7) | .0003 | 4.1 (2.1-7.8) | .00003 |
| CD56 | Positive | 2.7 (1.4-5.1) | .003 | 3.1 (1.5-6.1) | .001 |
| Stage | III/IV | 2.4 (1.2-4.8) | .01 | 2.8 (1.3-6.1) | .008 |
| PS | 2-4 | 3.4 (1.9-6.1) | .00003 | 2.5 (1.4-4.6) | .003 |
| EBV | Positive | 3.2 (1.6-6.7) | .002 | — | |
| ALK | Negative | 2.5 (1.4-4.9) | .001 | — | |
| B symptom | Present | 2.1 (1.1-3.7) | .01 | — | |
| Extranodal disease | ≧ 2 sites | 1.9 (1.1-3.5) | .03 | — | |
| LDH | > normal | 1.8 (1.0-3.1) | .05 | — | |
| Comparison with IPI category | |||||
| IPI category | H-I/H | 4.1 (2.2-7.3) | .000004 | 4.0 (2.2-7.2) | .00001 |
| CD56 | Positive | 2.7 (1.4-5.1) | .003 | 2.6 (1.3-5.0) | .004 |
CI indicates confidence interval; H, high; H-I, high-intermediate.
Final model.