Correlation of bone marrow microvessel study, measured in two different visual methods, with various patient characteristics in 114 patients with myelofibrosis with myeloid metaplasia
| Patient characteristics . | P . | |||||
|---|---|---|---|---|---|---|
| MVG . | VC . | CELL . | RF . | OS . | MC . | |
| Sex | .43 | .58 | .41 | .59 | .17 | .91 |
| Age | .28 | .18 | .96 | .06 | < .01 | .99 |
| Subsequent progression to splenectomy | .08 | .02 | .13 | .17 | .02 | .14 |
| Subsequent blastic transformation | .14 | .84 | .07 | .47 | .63 | .66 |
| Cytogenetic profile (normal vs abnormal) | .43 | .37 | .75 | .45 | .38 | .97 |
| Visual microvessel grading (MVG) | < .01 | .32 | .09 | < .01 | ||
| Visual microvessel counting (VC) | < .01 | .36 | .14 | .05 | ||
| Bone marrow cellularity (CELL) | .46 | .52 | .19 | < .01 | < .01 | |
| Degree of reticulin fibrosis (RF) | .97 | .06 | .19 | < .01 | .11 | |
| Osteosclerosis (OS) | .09 | .14 | < .01 | < .01 | < .01 | |
| Megakaryocyte clumping (MC) | .01 | .05 | < .01 | < .01 | < .01 | |
| Dupriez score | .91 | .29 | .47 | .12 | < .01 | .11 |
| Hemoglobin level | .16 | .23 | .05 | .02 | .06 | .05 |
| White blood cell count | .59 | .39 | .07 | .89 | .32 | .86 |
| Platelet count | .87 | .28 | .46 | .03 | .50 | .02 |
| Circulating blast percentage | .77 | .15 | < .01 | .27 | .26 | .02 |
| Need for red cell transfusion | .48 | .80 | .14 | .05 | .07 | .13 |
| Spleen size | .04 | < .01 | .59 | .03 | .41 | .07 |
| Liver size | .22 | .17 | .06 | .32 | .02 | .11 |
| History of weight loss | .78 | .21 | .05 | .26 | .31 | .1 |
| Patient characteristics . | P . | |||||
|---|---|---|---|---|---|---|
| MVG . | VC . | CELL . | RF . | OS . | MC . | |
| Sex | .43 | .58 | .41 | .59 | .17 | .91 |
| Age | .28 | .18 | .96 | .06 | < .01 | .99 |
| Subsequent progression to splenectomy | .08 | .02 | .13 | .17 | .02 | .14 |
| Subsequent blastic transformation | .14 | .84 | .07 | .47 | .63 | .66 |
| Cytogenetic profile (normal vs abnormal) | .43 | .37 | .75 | .45 | .38 | .97 |
| Visual microvessel grading (MVG) | < .01 | .32 | .09 | < .01 | ||
| Visual microvessel counting (VC) | < .01 | .36 | .14 | .05 | ||
| Bone marrow cellularity (CELL) | .46 | .52 | .19 | < .01 | < .01 | |
| Degree of reticulin fibrosis (RF) | .97 | .06 | .19 | < .01 | .11 | |
| Osteosclerosis (OS) | .09 | .14 | < .01 | < .01 | < .01 | |
| Megakaryocyte clumping (MC) | .01 | .05 | < .01 | < .01 | < .01 | |
| Dupriez score | .91 | .29 | .47 | .12 | < .01 | .11 |
| Hemoglobin level | .16 | .23 | .05 | .02 | .06 | .05 |
| White blood cell count | .59 | .39 | .07 | .89 | .32 | .86 |
| Platelet count | .87 | .28 | .46 | .03 | .50 | .02 |
| Circulating blast percentage | .77 | .15 | < .01 | .27 | .26 | .02 |
| Need for red cell transfusion | .48 | .80 | .14 | .05 | .07 | .13 |
| Spleen size | .04 | < .01 | .59 | .03 | .41 | .07 |
| Liver size | .22 | .17 | .06 | .32 | .02 | .11 |
| History of weight loss | .78 | .21 | .05 | .26 | .31 | .1 |
P values calculated by univariate analysis.
Values in boldface indicate that in a multivariate analysis the significant correlation between bone marrow microvessel density and subsequent need for splenectomy was accounted for by spleen size.