Bone marrow microvessel density estimation in 114 patients with myelofibrosis with myeloid metaplasia compared with a control group of 44 patients without bone marrow disease (normal controls), 15 patients with polycythemia vera, and 17 patients with essential thrombocythemia
| MVD evaluation methods . | MMM (n = 114 pts) . | Normal controls (n = 44 pts) . | Polycythemia vera (n = 15 pts) . | Essential thrombo-cythemia (n = 17 pts) . |
|---|---|---|---|---|
| Visual MVD grade | ||||
| 1 (normal) (%) | 2 (1.8) | 34 (77.3) | 4 (26.7) | 4 (23.5) |
| 2 (%) | 32 (28) | 10 (22.7) | 6 (40) | 11 (64.7) |
| 3 (%) | 43 (37.7) | 0 (0) | 5 (33) | 2 (12) |
| 4 (%) | 37 (32.5) | 0 (0) | 0 (0) | 0 (0) |
| Visual count, median (range) (vessels/high-power field) | 44.3 (7.8-112.9) | |||
| Image analysis, median (range) (% area occupied by vessels) | 7.3 (1.2-21.2) |
| MVD evaluation methods . | MMM (n = 114 pts) . | Normal controls (n = 44 pts) . | Polycythemia vera (n = 15 pts) . | Essential thrombo-cythemia (n = 17 pts) . |
|---|---|---|---|---|
| Visual MVD grade | ||||
| 1 (normal) (%) | 2 (1.8) | 34 (77.3) | 4 (26.7) | 4 (23.5) |
| 2 (%) | 32 (28) | 10 (22.7) | 6 (40) | 11 (64.7) |
| 3 (%) | 43 (37.7) | 0 (0) | 5 (33) | 2 (12) |
| 4 (%) | 37 (32.5) | 0 (0) | 0 (0) | 0 (0) |
| Visual count, median (range) (vessels/high-power field) | 44.3 (7.8-112.9) | |||
| Image analysis, median (range) (% area occupied by vessels) | 7.3 (1.2-21.2) |