Table 4.

Antigen-specific reactivity in peripheral blood mononuclear cells from patient no. 6 immunized with HER-2/neu peptide-pulsed dendritic cells

AntigensHIVGP2E75M1.1M1.2MAGECEA
Before therapy 0.2 0.1 0.2 0.2 0.2 0.2 0.2 
1. Vaccination 0.2 0.2 0.3 0.2 0.2 0.1 0.1 
3. Vaccination 0.1 0.3 1.2 0.2 0.1 0.2 0.2 
5. Vaccination 0.2 0.4 1.1 0.2 0.3 0.2 0.2 
7. Vaccination 0.2 0.2 0.8 0.5 0.6 0.2 0.3 
AntigensHIVGP2E75M1.1M1.2MAGECEA
Before therapy 0.2 0.1 0.2 0.2 0.2 0.2 0.2 
1. Vaccination 0.2 0.2 0.3 0.2 0.2 0.1 0.1 
3. Vaccination 0.1 0.3 1.2 0.2 0.1 0.2 0.2 
5. Vaccination 0.2 0.4 1.1 0.2 0.3 0.2 0.2 
7. Vaccination 0.2 0.2 0.8 0.5 0.6 0.2 0.3 

Refer to Table 2 for abbreviations.

F4-150

PBMNCs from each patient were incubated with autologous PBMNCs pulsed with the indicated peptides for 6 hours and IFN-γ production was assessed by flow cytometry after intracellular staining for IFN-γ in CD8 positive lymphocytes. Numbers represent the percentage of IFN-γ–expressing cells in the lymphocyte gate.

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