Patient characteristics
| Patient no. . | Age (y) . | Diagnosis . | Previous therapy (no. of cycles) . | Site of metastases . | Antigen . | No. of vaccinations . | Average no. of DCs × 10−6 (range) . |
|---|---|---|---|---|---|---|---|
| 1 | 58 | Breast | CTx (10), HTx (2) | Skin, pleura | HER-2/neu | 3 | 4.2 (2.0-8.0) |
| 2 | 42 | Breast | CTx (20) | Liver, bone | HER-2/neu | 3 | 5.4 (3.2-9.0) |
| 3 | 35 | Breast | CTx (16) | Liver, spleen | HER-2/neu | 3 | 7.2 (4.4-8.7) |
| 4 | 56 | Breast | CTx (12) | Liver | HER-2/neu | 5 | 5.1 (3.2-6.9) |
| 5 | 37 | Breast | CTx (23) | Liver, bone, LN | HER-2/neu | 4 | 2.8 (2.0-4.7) |
| 6 | 37 | Ovarian | CTx (9) | Peritoneum | HER-2/neu | 9 | 8.7 (2.5-17) |
| 7 | 57 | Ovarian | CTx (12) | Liver, peritoneum | MUC1 | 7 | 6.8 (4.2-8.8) |
| 8 | 37 | Breast | CTx (3), HD-CTx, HTx (2), Ovariectomy between 2nd and 3rd vaccination | Skin, ovaries | MUC1 | 9 | 7.7 (3.6-17) |
| 9 | 56 | Ovarian | CTx (18) | Liver, pleura, mediastinum | MUC1 | 3 | 2.8 (2.4-3.1) |
| 10 | 50 | Breast | CTx (4), HD-CTx, HTx (2) | Bone, skin | MUC1 | 7 | 8.0 (2.9-14) |
| Patient no. . | Age (y) . | Diagnosis . | Previous therapy (no. of cycles) . | Site of metastases . | Antigen . | No. of vaccinations . | Average no. of DCs × 10−6 (range) . |
|---|---|---|---|---|---|---|---|
| 1 | 58 | Breast | CTx (10), HTx (2) | Skin, pleura | HER-2/neu | 3 | 4.2 (2.0-8.0) |
| 2 | 42 | Breast | CTx (20) | Liver, bone | HER-2/neu | 3 | 5.4 (3.2-9.0) |
| 3 | 35 | Breast | CTx (16) | Liver, spleen | HER-2/neu | 3 | 7.2 (4.4-8.7) |
| 4 | 56 | Breast | CTx (12) | Liver | HER-2/neu | 5 | 5.1 (3.2-6.9) |
| 5 | 37 | Breast | CTx (23) | Liver, bone, LN | HER-2/neu | 4 | 2.8 (2.0-4.7) |
| 6 | 37 | Ovarian | CTx (9) | Peritoneum | HER-2/neu | 9 | 8.7 (2.5-17) |
| 7 | 57 | Ovarian | CTx (12) | Liver, peritoneum | MUC1 | 7 | 6.8 (4.2-8.8) |
| 8 | 37 | Breast | CTx (3), HD-CTx, HTx (2), Ovariectomy between 2nd and 3rd vaccination | Skin, ovaries | MUC1 | 9 | 7.7 (3.6-17) |
| 9 | 56 | Ovarian | CTx (18) | Liver, pleura, mediastinum | MUC1 | 3 | 2.8 (2.4-3.1) |
| 10 | 50 | Breast | CTx (4), HD-CTx, HTx (2) | Bone, skin | MUC1 | 7 | 8.0 (2.9-14) |
All patients were previously treated with surgery and radiation therapy.
DC indicates dendritic cells; CTx, chemotherapy; HD-CTx, high-dose chemotherapy; HTx, hormones; LN, lymph node.