Effect of plasminogen deficiency on pulmonary metastasis of circulating tumor cells
| Tumor cell line . | Mouse genotype . | Number of cells injected . | Pulmonary metastatic foci median (range) . | P (Mann-Whitney U 2-tailed) . |
|---|---|---|---|---|
| Lewis lung carcinoma | ||||
| Experiment 1 | Control (n = 12) | 2 × 105 | 19 (2-42) | > .18; NS |
| Plg− (n = 12) | 23 (11-46) | |||
| Experiment 2 | Control (n = 9) | 2 × 105 | 34 (0-63) | > .65; NS |
| Plg− (n = 10) | 36 (17-52) | |||
| B16-BL6 melanoma | ||||
| Experiment 1 | Control (n = 30) | 1.7 × 104 | 39 (2-106) | > .32; NS |
| Plg− (n = 16) | 47 (16-255) | |||
| Experiment 2 | Control (n = 13) | 1.7 × 104 | 53 (17-101) | > .50; NS |
| Plg− (n = 14) | 61 (11-172) |
| Tumor cell line . | Mouse genotype . | Number of cells injected . | Pulmonary metastatic foci median (range) . | P (Mann-Whitney U 2-tailed) . |
|---|---|---|---|---|
| Lewis lung carcinoma | ||||
| Experiment 1 | Control (n = 12) | 2 × 105 | 19 (2-42) | > .18; NS |
| Plg− (n = 12) | 23 (11-46) | |||
| Experiment 2 | Control (n = 9) | 2 × 105 | 34 (0-63) | > .65; NS |
| Plg− (n = 10) | 36 (17-52) | |||
| B16-BL6 melanoma | ||||
| Experiment 1 | Control (n = 30) | 1.7 × 104 | 39 (2-106) | > .32; NS |
| Plg− (n = 16) | 47 (16-255) | |||
| Experiment 2 | Control (n = 13) | 1.7 × 104 | 53 (17-101) | > .50; NS |
| Plg− (n = 14) | 61 (11-172) |
NS indicates not significant.