Effect of fibrinogen deficiency on pulmonary metastasis of circulating tumor cells
Tumor cell line . | Mouse genotype . | Number of cells injected . | Pulmonary metastatic foci median (range) . | P (Mann-Whitney U 2-tailed) . |
---|---|---|---|---|
Lewis lung carcinoma | ||||
Experiment 1 | Control (n = 16) | 1 × 105 | 13 (2-24) | < .007 |
Fib− (n = 16) | 0.5 (0-6) | |||
Experiment 2 | Control (n = 15) | 1 × 105 | 22 (0-142) | < .029 |
Fib− (n = 10) | 5 (0-16) | |||
Experiment 3 | Control (n = 16) | 2 × 105 | 46 (5-110) | < .004 |
Fib− (n = 10) | 11 (0-37) | |||
B16-BL6 melanoma | ||||
Experiment 1 | Control (n = 17) | 1.7 × 104 | 36 (3-163) | < .01 |
Fib− (n = 18) | 9 (2-66) | |||
Experiment 2 | Control (n = 20) | 1.7 × 104 | 9 (0-30) | < .009 |
Fib− (n = 14) | 3 (0-13) |
Tumor cell line . | Mouse genotype . | Number of cells injected . | Pulmonary metastatic foci median (range) . | P (Mann-Whitney U 2-tailed) . |
---|---|---|---|---|
Lewis lung carcinoma | ||||
Experiment 1 | Control (n = 16) | 1 × 105 | 13 (2-24) | < .007 |
Fib− (n = 16) | 0.5 (0-6) | |||
Experiment 2 | Control (n = 15) | 1 × 105 | 22 (0-142) | < .029 |
Fib− (n = 10) | 5 (0-16) | |||
Experiment 3 | Control (n = 16) | 2 × 105 | 46 (5-110) | < .004 |
Fib− (n = 10) | 11 (0-37) | |||
B16-BL6 melanoma | ||||
Experiment 1 | Control (n = 17) | 1.7 × 104 | 36 (3-163) | < .01 |
Fib− (n = 18) | 9 (2-66) | |||
Experiment 2 | Control (n = 20) | 1.7 × 104 | 9 (0-30) | < .009 |
Fib− (n = 14) | 3 (0-13) |