Table 1.

Effect of fibrinogen deficiency on pulmonary metastasis of circulating tumor cells

Tumor cell lineMouse genotypeNumber of cells injectedPulmonary metastatic foci
median (range)
P
(Mann-Whitney U 2-tailed)
Lewis lung carcinoma     
 Experiment 1 Control (n = 16) 1 × 105 13 (2-24) < .007 
 Fib (n = 16)  0.5 (0-6)  
 Experiment 2 Control (n = 15) 1 × 105 22 (0-142) < .029 
 Fib (n = 10)  5 (0-16)  
 Experiment 3 Control (n = 16) 2 × 105 46 (5-110) < .004 
 Fib (n = 10)  11 (0-37)  
B16-BL6 melanoma     
 Experiment 1 Control (n = 17) 1.7 × 104 36 (3-163) < .01 
 Fib (n = 18)  9 (2-66)  
 Experiment 2 Control (n = 20) 1.7 × 104 9 (0-30) < .009 
 Fib (n = 14)  3 (0-13)  
Tumor cell lineMouse genotypeNumber of cells injectedPulmonary metastatic foci
median (range)
P
(Mann-Whitney U 2-tailed)
Lewis lung carcinoma     
 Experiment 1 Control (n = 16) 1 × 105 13 (2-24) < .007 
 Fib (n = 16)  0.5 (0-6)  
 Experiment 2 Control (n = 15) 1 × 105 22 (0-142) < .029 
 Fib (n = 10)  5 (0-16)  
 Experiment 3 Control (n = 16) 2 × 105 46 (5-110) < .004 
 Fib (n = 10)  11 (0-37)  
B16-BL6 melanoma     
 Experiment 1 Control (n = 17) 1.7 × 104 36 (3-163) < .01 
 Fib (n = 18)  9 (2-66)  
 Experiment 2 Control (n = 20) 1.7 × 104 9 (0-30) < .009 
 Fib (n = 14)  3 (0-13)  
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