Frequency of RBC antigens in the local donor population and RBC phenotype available on 20 Asian thalassemia patients
| RBC antigen . | All local donors (n = 802) . | White donors (n = 352) . | Asian donors (n = 103)† . | Asian donors (n = 435)† . | Asian patients (n = 20) . | Average antigen frequency (Asians) . | P . |
|---|---|---|---|---|---|---|---|
| s* | 93.1 | 91.7 | 90.5 | 99.5 | 100 | 97.86 | — |
| Fya* | 77.1 | 60.2 | 89.5 | 98.2 | 95 | 96.48 | — |
| C* | 51.7 | 50.5 | 84.4 | 95.7 | 95 | 93.59 | — |
| E* | 95.5 | 95.4 | 88.5 | 93.7 | 100 | 92.97 | — |
| M | NA | NA | NA | 83 | 75 | 82.65 | — |
| Jkb* | 57.1 | 70.4 | 67 | 81 | 85 | 78.56 | — |
| N | NA | NA | NA | 72 | 53.8 | 71.20 | — |
| Jka* | 53.7 | 69.3 | 68 | 68 | 75 | 68.25 | — |
| Leb | NA | NA | NA | 64 | 66.6 | 64.11 | — |
| C* | 80.4 | 77.8 | 43.7 | 53.8 | 35 | 51.26 | < .0001 |
| E* | 21.4 | 19 | 32.0 | 43 | 25 | 40.32 | — |
| P1* | NA | NA | NA | 40 | 33.3 | 39.71 | — |
| Lea | NA | NA | NA | 20 | 40 | 20.88 | — |
| Fyb* | 63 | 78.7 | 16.8 | 18 | 20 | 17.85 | < .0001 |
| S* | 40.5 | 51.4 | 15.6 | 12.7 | 20 | 13.50 | .001 |
| K* | —‡ | 9‡ | 0 | 0 | 1.0 | 0.3 | < .0001 |
| RBC antigen . | All local donors (n = 802) . | White donors (n = 352) . | Asian donors (n = 103)† . | Asian donors (n = 435)† . | Asian patients (n = 20) . | Average antigen frequency (Asians) . | P . |
|---|---|---|---|---|---|---|---|
| s* | 93.1 | 91.7 | 90.5 | 99.5 | 100 | 97.86 | — |
| Fya* | 77.1 | 60.2 | 89.5 | 98.2 | 95 | 96.48 | — |
| C* | 51.7 | 50.5 | 84.4 | 95.7 | 95 | 93.59 | — |
| E* | 95.5 | 95.4 | 88.5 | 93.7 | 100 | 92.97 | — |
| M | NA | NA | NA | 83 | 75 | 82.65 | — |
| Jkb* | 57.1 | 70.4 | 67 | 81 | 85 | 78.56 | — |
| N | NA | NA | NA | 72 | 53.8 | 71.20 | — |
| Jka* | 53.7 | 69.3 | 68 | 68 | 75 | 68.25 | — |
| Leb | NA | NA | NA | 64 | 66.6 | 64.11 | — |
| C* | 80.4 | 77.8 | 43.7 | 53.8 | 35 | 51.26 | < .0001 |
| E* | 21.4 | 19 | 32.0 | 43 | 25 | 40.32 | — |
| P1* | NA | NA | NA | 40 | 33.3 | 39.71 | — |
| Lea | NA | NA | NA | 20 | 40 | 20.88 | — |
| Fyb* | 63 | 78.7 | 16.8 | 18 | 20 | 17.85 | < .0001 |
| S* | 40.5 | 51.4 | 15.6 | 12.7 | 20 | 13.50 | .001 |
| K* | —‡ | 9‡ | 0 | 0 | 1.0 | 0.3 | < .0001 |
All local donors include mostly white (85%) and other ethnicities (15%). Asian donor phenotypes were collected during 2 separate time periods. Significant antigen frequency differences between white and Asian RBCs are on the rows with P values given. P was calculated for the antigens appearing in a higher frequency among the white (and total) donor population compared to the average frequency found among Asian patients. NA indicates not available.
Indicates clinically significant antibodies (ie, can cause a hemolytic transfusion reaction or hemolytic disease of the newborn).
Donors' phenotypes were collected in 2 separate time periods.
Frequency of Kell (K) antigen was not always examined. Therefore the known frequency among white people was used.