Relative risk for engraftment endpoints and transplant-related events
| Variable . | No. patients . | Relative risk (95% CI) . | |
|---|---|---|---|
| Univariate . | Multivariate . | ||
| TNC/kg (before cryopreservation, ×106)* | |||
| ≥100 | 21 | 4.8 (2.8-8.4) P < .001 | 1.5 (0.6-3.9) P = .4 |
| 50-99 | 41 | 1.7 (1.1-2.8) P = .024 | 0.7 (0.4-1.3)P = .3 |
| 25-49 | 67 | 1.8 (1.2-2.8) P = .006 | 1.2 (0.8-1.9) P = .4 |
| <25 | 61 | 1.0 | 1.0 |
| CFC/kg (before cryopreservation, ×103)* | |||
| ≥200 | 28 | 5.2 (3.0-9.0)P < .001 | 4.7 (2.0-11.1) P < .001 |
| 100-199 | 43 | 4.2 (2.5-7.0) P < .001 | 4.7 (2.6-8.8) P < .001 |
| 50-99 | 61 | 2.4 (1.5-3.8)P < .001 | 2.4 (1.5-3.9) P < .001 |
| <50 | 58 | 1.0 | 1.0 |
| TNC/kg (before cryopreservation, ×106)† | |||
| ≥100 | 21 | 2.0 (0.99-4.0)P = .052 | 0.4 (0.1-1.3) P = .12 |
| 50-99 | 40 | 0.9 (1.3-4.6) P = .005 | 1.1 (0.5-2.4)P = .9 |
| 25-49 | 64 | 1.1 (0.6-2.0) P = .8 | 0.8 (0.4-1.5) P = .5 |
| <25 | 55 | 1.0 | 1.0 |
| CFC/kg (before cryopreservation, ×103)† | |||
| ≥200 | 28 | 4.4 (2.1-9.1)P < .001 | 8.1 (2.7-24.2) P < .001 |
| 100-199 | 40 | 3.5 (1.8-6.9) P < .001 | 4.0 (1.8-8.7) P = .001 |
| 50-99 | 59 | 2.0 (1.1-3.9)P = .034 | 2.0 (1.0-3.9) P = .37 |
| <50 | 53 | 1.0 | 1.0 |
| TNC/kg (before cryopreservation, ×106)‡ | |||
| 100 | 22 | 1.0 | 1.0 |
| 50-99 | 42 | 0.9 (0.4-2.0) P = .9 | 0.9 (0.3-2.6)P = .9 |
| 25-49 | 72 | 1.1 (0.6-2.2) P = .8 | 1.0 (0.3-3.0) P = 1 |
| <25 | 66 | 2.0 (1.02-3.8)P = .04 | 1.5 (0.5-4.9) P = .4 |
| CFC/kg (before cryopreservation, ×103)‡ | |||
| 200 | 29 | 1.0 | 1.0 |
| 100-199 | 45 | 1.1 (0.5-2.1) P = .8 | 1.1 (0.4-2.9)P = .9 |
| 50-99 | 64 | 1.0 (0.5-1.9) P = .9 | 0.8 (0.3-2.3) P = .7 |
| <50 | 64 | 2.3 (1.2-4.2)P = .009 | 1.7 (0.6-4.9) P = .4 |
| Variable . | No. patients . | Relative risk (95% CI) . | |
|---|---|---|---|
| Univariate . | Multivariate . | ||
| TNC/kg (before cryopreservation, ×106)* | |||
| ≥100 | 21 | 4.8 (2.8-8.4) P < .001 | 1.5 (0.6-3.9) P = .4 |
| 50-99 | 41 | 1.7 (1.1-2.8) P = .024 | 0.7 (0.4-1.3)P = .3 |
| 25-49 | 67 | 1.8 (1.2-2.8) P = .006 | 1.2 (0.8-1.9) P = .4 |
| <25 | 61 | 1.0 | 1.0 |
| CFC/kg (before cryopreservation, ×103)* | |||
| ≥200 | 28 | 5.2 (3.0-9.0)P < .001 | 4.7 (2.0-11.1) P < .001 |
| 100-199 | 43 | 4.2 (2.5-7.0) P < .001 | 4.7 (2.6-8.8) P < .001 |
| 50-99 | 61 | 2.4 (1.5-3.8)P < .001 | 2.4 (1.5-3.9) P < .001 |
| <50 | 58 | 1.0 | 1.0 |
| TNC/kg (before cryopreservation, ×106)† | |||
| ≥100 | 21 | 2.0 (0.99-4.0)P = .052 | 0.4 (0.1-1.3) P = .12 |
| 50-99 | 40 | 0.9 (1.3-4.6) P = .005 | 1.1 (0.5-2.4)P = .9 |
| 25-49 | 64 | 1.1 (0.6-2.0) P = .8 | 0.8 (0.4-1.5) P = .5 |
| <25 | 55 | 1.0 | 1.0 |
| CFC/kg (before cryopreservation, ×103)† | |||
| ≥200 | 28 | 4.4 (2.1-9.1)P < .001 | 8.1 (2.7-24.2) P < .001 |
| 100-199 | 40 | 3.5 (1.8-6.9) P < .001 | 4.0 (1.8-8.7) P = .001 |
| 50-99 | 59 | 2.0 (1.1-3.9)P = .034 | 2.0 (1.0-3.9) P = .37 |
| <50 | 53 | 1.0 | 1.0 |
| TNC/kg (before cryopreservation, ×106)‡ | |||
| 100 | 22 | 1.0 | 1.0 |
| 50-99 | 42 | 0.9 (0.4-2.0) P = .9 | 0.9 (0.3-2.6)P = .9 |
| 25-49 | 72 | 1.1 (0.6-2.2) P = .8 | 1.0 (0.3-3.0) P = 1 |
| <25 | 66 | 2.0 (1.02-3.8)P = .04 | 1.5 (0.5-4.9) P = .4 |
| CFC/kg (before cryopreservation, ×103)‡ | |||
| 200 | 29 | 1.0 | 1.0 |
| 100-199 | 45 | 1.1 (0.5-2.1) P = .8 | 1.1 (0.4-2.9)P = .9 |
| 50-99 | 64 | 1.0 (0.5-1.9) P = .9 | 0.8 (0.3-2.3) P = .7 |
| <50 | 64 | 2.3 (1.2-4.2)P = .009 | 1.7 (0.6-4.9) P = .4 |
TNC indicates total nucleated cell; CFC, colony-forming cell.
Myeloid engraftment (time to absolute neutrophil count, 500/μL).
Platelet engraftment (time to platelet count 50,000/μL).
Transplant-related events during first 2 years after transplantation (autologous reconstitution, other transplants, and death; relapse censored). Two patients who did not survive after the day of transplantation are excluded.