Table 1. Variables in patients with... | American Society of Hematology

Table 1.

Variables in patients with hemoglobin H (HbH) and HbH/constant spring (HbH/CS)

Patient no.	Hgb (g/L)	MCV (fl)	SI (μmol/L)	TIBC (μmol/L)	Tf sat (%)	PITR^*	RBC ⁵⁹Fe use (%)	⁵¹Cr RBC T½ (days)
HbH
12	89	62	18	42	44.1	1.4	71.9	21.3
13	95	78	22	34	64.7	2.3	72.7	16.0
14	90	79	17	39	43.1	1.7	79.8	15.8
15	78	63	24	40	90.4	2.7	—	9.7
Mean ± SD	88 ± 7	70.5 ± 9.3	20.3 ± 3.3	38.8 ± 3.4	60.6 ± 22.2	2 ± 0.6	74.8 ± 4.3	15.7 ± 4.7
HbH/CS
16	91	78	30	40	75.0	3.5	62.0	6.8
17	113	79	27	51	53.0	3.4	56.6	12.0
18	82	90	32	41	77.6	4.2	61.6	9.3
19	127	89	42	34	100.0	2.4	—	6.8
20	95	79	35	41	94.1	5.7	60.9	6.2
21	85	77	29	45	64.1	3.0	54.4	8.7
Mean ± SD	99 ± 18	82 ± 5.9	32.5 ± 5.4	42 ± 5.7	77.3 ± 17.7	3.7 ± 1.1	59.1 ± 3.4	8.3 ± 2.2
Pvalue	.22	.08	<.001	.29	.26	.02	0.01	0.05
Normal	—	84.9 ± 8.1	20.6 ± 5.8	55.9 ± 7.2	35.8 ± 8.9	0.72	80	25.7 ± 0.9

Patient no.	Hgb (g/L)	MCV (fl)	SI (μmol/L)	TIBC (μmol/L)	Tf sat (%)	PITR^*	RBC ⁵⁹Fe use (%)	⁵¹Cr RBC T½ (days)
HbH
12	89	62	18	42	44.1	1.4	71.9	21.3
13	95	78	22	34	64.7	2.3	72.7	16.0
14	90	79	17	39	43.1	1.7	79.8	15.8
15	78	63	24	40	90.4	2.7	—	9.7
Mean ± SD	88 ± 7	70.5 ± 9.3	20.3 ± 3.3	38.8 ± 3.4	60.6 ± 22.2	2 ± 0.6	74.8 ± 4.3	15.7 ± 4.7
HbH/CS
16	91	78	30	40	75.0	3.5	62.0	6.8
17	113	79	27	51	53.0	3.4	56.6	12.0
18	82	90	32	41	77.6	4.2	61.6	9.3
19	127	89	42	34	100.0	2.4	—	6.8
20	95	79	35	41	94.1	5.7	60.9	6.2
21	85	77	29	45	64.1	3.0	54.4	8.7
Mean ± SD	99 ± 18	82 ± 5.9	32.5 ± 5.4	42 ± 5.7	77.3 ± 17.7	3.7 ± 1.1	59.1 ± 3.4	8.3 ± 2.2
Pvalue	.22	.08	<.001	.29	.26	.02	0.01	0.05
Normal	—	84.9 ± 8.1	20.6 ± 5.8	55.9 ± 7.2	35.8 ± 8.9	0.72	80	25.7 ± 0.9

Hgb indicates hemoglobin level; MCV, mean corpuscular volume; SI, serum iron; TIBC, total iron-binding capacity; Tf sat, transferrin iron saturation; PITR, plasma iron turnover rate; RBC, red blood cell;⁵⁹Fe, iron 59; ⁵¹Cr, chromium 51; and T½, terminal half-life.

Expressed as mg Fe/L whole blood/day.

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