Association between CCR5 and SDF1 genotypes and KS in HIV-infected men
Genotype . | No. (%) of men with KS . | No. (%) of men without KS . | Evidence for association (P value) . | |
---|---|---|---|---|
Locus . | Genotype . | |||
SDF1 (G801A) | ||||
AA | 2 (1.7) | 5 (4.0) | .45 (F) | |
AG | 39 (33.9) | 31 (25.0) | .23 (M) | .13 |
GG | 74 (64.3) | 88 (71.0) | .27 | |
CCR5 (Δ32) | ||||
11 | 104 (90.4) | 105 (84.0) | ||
12 | 11 (9.6) | 20 (16.0) | .14 | —3-150 |
22 | 0 | 0 |
Genotype . | No. (%) of men with KS . | No. (%) of men without KS . | Evidence for association (P value) . | |
---|---|---|---|---|
Locus . | Genotype . | |||
SDF1 (G801A) | ||||
AA | 2 (1.7) | 5 (4.0) | .45 (F) | |
AG | 39 (33.9) | 31 (25.0) | .23 (M) | .13 |
GG | 74 (64.3) | 88 (71.0) | .27 | |
CCR5 (Δ32) | ||||
11 | 104 (90.4) | 105 (84.0) | ||
12 | 11 (9.6) | 20 (16.0) | .14 | —3-150 |
22 | 0 | 0 |
A total of 115 men with KS and 126 without KS were studied. Genotypes for CCR5 and SDF1 were determined for a population of North American white men who acquired HIV infection through sex with other men. A χ2 test or the Mehta version of the Fisher exact test (M) was used to test the hypothesis at each locus (3 × 2 tables with 2 degrees of freedom) and for each of 3 possible genotypes (2 × 2 table). Not all samples were amplified at each locus.
Because the 2/2 genotype was not observed, only a 2 × 2 test was performed.
F indicates Fisher exact test.