Clinical and laboratory features of the Dogon malaria cases
| . | Cases, no. . | Mean age, y (IQR) . | Mean hct, % (IQR) . | Mean parasitemia, ×103/μL (IQR) . | Splenomegaly, no. cases (%) . | Rural, no. cases (%) . | Urban, no. cases (%) . |
|---|---|---|---|---|---|---|---|
| Total with uncomplicated malaria | 488 | 8.1 (3-12) | 33 (28-36) | 57 (8-79) | 93 (19) | 30 (7) | 390 (93) |
| Ep < 1 × 105/μL (control cases) | 391 | 9.1 (3-12) | 33 (29-37) | 26 (6-37) | 70 (18) | 19 (6) | 315 (94) |
| Ep > 1 × 105/μL | 97 | 4.2* (2-5) | 30* (26-34) | 182 (118-216) | 23 (24) | 11 (13) | 75 (87) |
| Total with severe malaria | 67 | 4.3† (1-4) | 23† (17-29.5) | 322 (51-558) | 36 (54) | 19 (28)‡ | 48 (72) |
| Cerebral manifestations | 34 | 3.8 (2-4) | 24 (19-29) | 177 (50-229) | 17 (50) | 8 (23) | 26 (77) |
| Severe anemia (hct<15%) | 12 | 1.0 (1-2) | 12 (11.8-13) | 138 (10-124) | 10 (83) | 5 (45) | 6 (55) |
| Hyperparasitemia (Ep>5×105/μL) | 18 | 8.1 (3-6) | 27 (23.8-30) | 904 (641-1085) | 5 (28) | 3 (17) | 15 (83) |
| Respiratory distress or shock | 6 | 1.0 (0.3-1) | 25 (21-28.8) | 127 (72-203) | 4 (66) | 4 (67) | 2 (33) |
| Severe prostration | 6 | 1.5 (1-1.8) | 29 (25.3-32) | 100 (21-169) | 2 (33) | 4 (67) | 2 (33) |
| . | Cases, no. . | Mean age, y (IQR) . | Mean hct, % (IQR) . | Mean parasitemia, ×103/μL (IQR) . | Splenomegaly, no. cases (%) . | Rural, no. cases (%) . | Urban, no. cases (%) . |
|---|---|---|---|---|---|---|---|
| Total with uncomplicated malaria | 488 | 8.1 (3-12) | 33 (28-36) | 57 (8-79) | 93 (19) | 30 (7) | 390 (93) |
| Ep < 1 × 105/μL (control cases) | 391 | 9.1 (3-12) | 33 (29-37) | 26 (6-37) | 70 (18) | 19 (6) | 315 (94) |
| Ep > 1 × 105/μL | 97 | 4.2* (2-5) | 30* (26-34) | 182 (118-216) | 23 (24) | 11 (13) | 75 (87) |
| Total with severe malaria | 67 | 4.3† (1-4) | 23† (17-29.5) | 322 (51-558) | 36 (54) | 19 (28)‡ | 48 (72) |
| Cerebral manifestations | 34 | 3.8 (2-4) | 24 (19-29) | 177 (50-229) | 17 (50) | 8 (23) | 26 (77) |
| Severe anemia (hct<15%) | 12 | 1.0 (1-2) | 12 (11.8-13) | 138 (10-124) | 10 (83) | 5 (45) | 6 (55) |
| Hyperparasitemia (Ep>5×105/μL) | 18 | 8.1 (3-6) | 27 (23.8-30) | 904 (641-1085) | 5 (28) | 3 (17) | 15 (83) |
| Respiratory distress or shock | 6 | 1.0 (0.3-1) | 25 (21-28.8) | 127 (72-203) | 4 (66) | 4 (67) | 2 (33) |
| Severe prostration | 6 | 1.5 (1-1.8) | 29 (25.3-32) | 100 (21-169) | 2 (33) | 4 (67) | 2 (33) |
The mean age, hematocrit, and parasitemia are listed with interquartile ranges (IQRs) in parentheses. The number of rural and urban cases for which residential information was available are listed. Hct indicates hematocrit.
Significant difference in age and hematocrit between uncomplicatedEP>1×105/μL cases and control cases (P<.001 by the Mann-Whitney U test andP<.001 by the Student t test, respectively).
Significant difference in age and hematocrit between severe cases and control cases (P<.001 by the Student t test andP<.001 by the Welch t test, respectively).
Significant difference between rural proportion of severe cases and rural proportion of uncomplicated control cases (28% vs 6%;P<.0000001 by the chi-square test, with 1 degree of freedom).