Karyotype, immunophenotype, and immunohistochemical stain for factor VIII and platelet antigen expression of patients with acute megakaryocytic leukemia
| Patient . | Karyotype . | Immunophenotype/Immunohistochemical stain . |
|---|---|---|
| 1 | 46,XX,t(3;3)(q21;q26) | POX−,HLA−DR+,Ly ag−,My ag−,CD41+,H−ag− |
| 2 | N/A | N/A/FVIII+ |
| 3 | 46,XY,inv(3)(q21;q26) | NA/PH ag+ |
| 4 | 46,XY,t(3;3)(q21;q26) | POX+,HLA−DR+,CD34+,CD2+,CD7+,My ag+,Mono ag+/FVIII+ |
| 5 | 46,XX | POX−,HLA−DR+,CD34+,CD7+,CD33+,CD13+,Plt ag− |
| 6 | 46,XX,−7,+mar[4]/47,XX,+mar[2]/92,XXXX,−7,−7,+marx2[3]/46,XX[11] | POX−,HLA−DR−,CD34+,Ly ag−,My ag−,CD41+,H ag+ |
| 7 | N/A | POX−,HLA−DR+,CD34+,CD117+,My ag+,CD41+,CD61+,CD36+/FVIII+ |
| 8 | 46,XY,t(8;17)(p21;p13)[3]/46,XY[25] | POX−,HLA-DR+,CD34+,TdT+,CD2+,My ag+,CD41+/FVIII+ |
| 9 | N/A | N/A/FVIII+ |
| 10 | N/A | N/A |
| 11 | N/A | N/A/FVIII+ |
| 12 | N/A | N/A |
| 13 | N/A | N/A |
| 14 | N/A | N/A |
| 15 | 46,XX | POX+,HLA-DR−,My ag+,Mono ag+,Plt ag− |
| 16 | N/A | N/A |
| 17 | N/A | N/A |
| 18 | N/A | N/A |
| 19 | N/A | N/A |
| 20 | 46,XY,t(3;12)(q25;p11.2),−13,+mar[6] | N/A/FVIII+ |
| Patient . | Karyotype . | Immunophenotype/Immunohistochemical stain . |
|---|---|---|
| 1 | 46,XX,t(3;3)(q21;q26) | POX−,HLA−DR+,Ly ag−,My ag−,CD41+,H−ag− |
| 2 | N/A | N/A/FVIII+ |
| 3 | 46,XY,inv(3)(q21;q26) | NA/PH ag+ |
| 4 | 46,XY,t(3;3)(q21;q26) | POX+,HLA−DR+,CD34+,CD2+,CD7+,My ag+,Mono ag+/FVIII+ |
| 5 | 46,XX | POX−,HLA−DR+,CD34+,CD7+,CD33+,CD13+,Plt ag− |
| 6 | 46,XX,−7,+mar[4]/47,XX,+mar[2]/92,XXXX,−7,−7,+marx2[3]/46,XX[11] | POX−,HLA−DR−,CD34+,Ly ag−,My ag−,CD41+,H ag+ |
| 7 | N/A | POX−,HLA−DR+,CD34+,CD117+,My ag+,CD41+,CD61+,CD36+/FVIII+ |
| 8 | 46,XY,t(8;17)(p21;p13)[3]/46,XY[25] | POX−,HLA-DR+,CD34+,TdT+,CD2+,My ag+,CD41+/FVIII+ |
| 9 | N/A | N/A/FVIII+ |
| 10 | N/A | N/A |
| 11 | N/A | N/A/FVIII+ |
| 12 | N/A | N/A |
| 13 | N/A | N/A |
| 14 | N/A | N/A |
| 15 | 46,XX | POX+,HLA-DR−,My ag+,Mono ag+,Plt ag− |
| 16 | N/A | N/A |
| 17 | N/A | N/A |
| 18 | N/A | N/A |
| 19 | N/A | N/A |
| 20 | 46,XY,t(3;12)(q25;p11.2),−13,+mar[6] | N/A/FVIII+ |
POX = myeloperoxidase by antibody staining; Ly ag = all lymphoid antigens (T-antigens: intracytoplasmic CD3, CD2, CD7, surface CD3, CD4, CD8; B-antigens: intracytoplasmic CD22, CD19, CD24, surface CD22, CD20); My ag = all myeloid antigens (CD33, CD13, CD65s, CD15); Mono ag = monocytic antigens (CD11b, CD14); TdT = terminal transferase; H ag = blood group H antigen; Plt ag; all platelet-specific antigens; FVIII = factor VIII antigen expression.