Summary of hematologic responses to 5-aza-CdR
Patient . | Dose . | HbF % . | F cells % . | γ/β + γ . | Hb g/dL . | Neutrophils . | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
Pre . | Post . | Pre . | Post . | Pre . | Post . | Pre . | Post . | Pre . | Nadir . | ||
1 | 0.15 | 2.3 | 9.6 | 25 | 49 | 3.3 | 9.4 | 7.3 | 8.1 | 2.7 | 1.7 |
0.25 | 10.7 | 48 | 13.1 | 7.4 | 8.5 | 4.0 | 0.7 | ||||
2 | 0.15 | 4.3 | 12.4 | 2.4 | 13.7 | 8.5 | 9.6 | 7.0 | 0.7 | ||
0.25 | 15 | 22.0 | 8.7 | 10.0 | 6.3 | 0.3 | |||||
3 | 0.20 | 0.9 | 11.3 | 8 | 51 | 1.6 | 11.6 | 7.7 | 9.3 | 9.6 | 3.8 |
0.30 | 13.9 | 54 | 12.5 | 8.6 | 9.0 | 7.8 | 2.1 | ||||
4 | 0.20 | 0.5 | 8.6 | 3 | 36 | <1.0 | 10.1 | 7.5 | 8.6 | 12.1 | 2.9 |
0.30 | 11.2 | 47 | 12.0 | 8.5 | 9.0 | 12.5 | 2.3 | ||||
5 | 0.15 | 3.4 | 9.5 | 18 | 51 | 3.4 | 6.4 | NA | NA | NA | NA |
0.25 | 13.1 | 56 | 14.4 | 8.8 | 9.4 | 4.5 | 1.8 | ||||
6 | 0.15 | 4.3 | 15.9 | 5.0 | 12.4 | 8.8 | 10.6 | 5.4 | 2.8 | ||
7 | 0.20 | 3.4 | 18.8 | 28 | 77 | 4.1 | 14.7 | 9.2 | 9.5 | 4.3 | 1.6 |
0.30 | 20.2 | 74 | 17.0 | 8.5 | 10.1 | 5.0 | 0.4 | ||||
8 | 0.15 | 8.3 | 18.1 | 44 | 76 | 4.7 | 22.0 | 8.6 | 9.1 | 3.7 | 1.8 |
± SD | 3.6 ± 2.4 | 13.5 ± 3.7 | 21 ± 14.8 | 55.3 ± 13.5 | 3.2 ± 1.4 | 13.7 ± 4.4 | 8.3 ± 0.6 | 9.3 ± 0.7* | 6.2 ± 2.9 | 1.4 ± 1.0 |
Patient . | Dose . | HbF % . | F cells % . | γ/β + γ . | Hb g/dL . | Neutrophils . | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
Pre . | Post . | Pre . | Post . | Pre . | Post . | Pre . | Post . | Pre . | Nadir . | ||
1 | 0.15 | 2.3 | 9.6 | 25 | 49 | 3.3 | 9.4 | 7.3 | 8.1 | 2.7 | 1.7 |
0.25 | 10.7 | 48 | 13.1 | 7.4 | 8.5 | 4.0 | 0.7 | ||||
2 | 0.15 | 4.3 | 12.4 | 2.4 | 13.7 | 8.5 | 9.6 | 7.0 | 0.7 | ||
0.25 | 15 | 22.0 | 8.7 | 10.0 | 6.3 | 0.3 | |||||
3 | 0.20 | 0.9 | 11.3 | 8 | 51 | 1.6 | 11.6 | 7.7 | 9.3 | 9.6 | 3.8 |
0.30 | 13.9 | 54 | 12.5 | 8.6 | 9.0 | 7.8 | 2.1 | ||||
4 | 0.20 | 0.5 | 8.6 | 3 | 36 | <1.0 | 10.1 | 7.5 | 8.6 | 12.1 | 2.9 |
0.30 | 11.2 | 47 | 12.0 | 8.5 | 9.0 | 12.5 | 2.3 | ||||
5 | 0.15 | 3.4 | 9.5 | 18 | 51 | 3.4 | 6.4 | NA | NA | NA | NA |
0.25 | 13.1 | 56 | 14.4 | 8.8 | 9.4 | 4.5 | 1.8 | ||||
6 | 0.15 | 4.3 | 15.9 | 5.0 | 12.4 | 8.8 | 10.6 | 5.4 | 2.8 | ||
7 | 0.20 | 3.4 | 18.8 | 28 | 77 | 4.1 | 14.7 | 9.2 | 9.5 | 4.3 | 1.6 |
0.30 | 20.2 | 74 | 17.0 | 8.5 | 10.1 | 5.0 | 0.4 | ||||
8 | 0.15 | 8.3 | 18.1 | 44 | 76 | 4.7 | 22.0 | 8.6 | 9.1 | 3.7 | 1.8 |
± SD | 3.6 ± 2.4 | 13.5 ± 3.7 | 21 ± 14.8 | 55.3 ± 13.5 | 3.2 ± 1.4 | 13.7 ± 4.4 | 8.3 ± 0.6 | 9.3 ± 0.7* | 6.2 ± 2.9 | 1.4 ± 1.0 |