Clinical features and outcomes according to karyotype
| . | Patients, no. . | Median age, y (quartiles) . | Race, % . | Sex, M:F . | Median WBC, ×103/μL (quartiles) . | Failed . | Expected . | P . | ||
|---|---|---|---|---|---|---|---|---|---|---|
| White/Other . | Black . | Hispanic . | ||||||||
| Total | 354 | 8.2 (5.3-12.6) | 76.6 | 15 | 8 | 3.0 | 70 (19-189) | — | ||
| Normal karotype | 153 | 8.2 (5.4-12.9) | 77 | 16 | 7 | 3.1 | 78 (19-196) | 68 | 83.7 | .019 |
| Abnormal karotype | 201 | 8.3 (5.2-11.9) | 77 | 14 | 9 | 2.9 | 62 (19-188) | 114 | 98.3 | — |
| Hypodiploid | 16 | 7.9 (5.7-10.0) | 68 | 19 | 13 | 4.3 | 76 (15-107) | 12 | 9.0 | .63 |
| Pseudodiploid | 124 | 7.8 (4.8-11.8) | 75 | 15 | 10 | 4.0 | 66 (21-233) | 67 | 72.2 | — |
| Hyperdiploid, 47-50 chrom. | 47 | 8.5 (5.4-13.2) | 78 | 13 | 9 | 2.1 | 60 (16-161) | 26 | 25.5 | — |
| Hyperdiploid, >50 chrom. | 14 | 8.5 (7.1-12.3) | 86 | 7 | 7 | 0.75 | 21 (11-71) | 9 | 7.3 | — |
| Any translocation | 122 | 7.8 (4.8-11.9) | 70 | 19 | 11 | 2.7 | 65 (20-189) | 66 | 70.1 | .43 |
| Any del chrom. | 91 | 8.5 (4.9-11.8) | 75 | 13 | 12 | 3.3 | 60 (20-199) | 57 | 64.9 | .14 |
| Any der chrom. | 51 | 9.8 (5.3-14.0) | 72 | 20 | 8 | 2.4 | 77 (14-202) | 35 | 25.7 | .037 |
| Any 14q11-13 abnormality | 43 | 8.2 (4.7-13.7) | 65 | 19 | 16 | 4.4 | 85 (25-391) | 19 | 27.0 | .08 |
| Del(6q) | 38 | 8.8 (5.0-11.3) | 76 | 11 | 13 | 4.4 | 75 (39-340) | 27 | 20.0 | .087 |
| +8 | 22 | 7.0 (4.2-12.9) | 86 | 14 | 0 | 1.8 | 56 (10-154) | 12 | 11.0 | .76 |
| Loss of 9p* | 32 | 9.0 (6.3-12.8) | 78 | 13 | 9 | 3.0 | 83 (26-219) | 16 | 18.3 | .56 |
| t(11;14) | 14 | 6.8 (4.1-11.8) | 72 | 7 | 21 | 2.5 | 407 (58-466) | 8 | 7.8 | .94 |
| t(10;14) | 12 | 7.5 (5.1-9.4) | 67 | 33 | 0 | 5.0 | 54 (14-130) | 3 | 9.7 | .024 |
| Loss of 5q† | 19 | 7.4 (4.5-11.1) | 63 | 26 | 11 | 3.8 | 19 (3-96) | 15 | 8.5 | .067 |
| . | Patients, no. . | Median age, y (quartiles) . | Race, % . | Sex, M:F . | Median WBC, ×103/μL (quartiles) . | Failed . | Expected . | P . | ||
|---|---|---|---|---|---|---|---|---|---|---|
| White/Other . | Black . | Hispanic . | ||||||||
| Total | 354 | 8.2 (5.3-12.6) | 76.6 | 15 | 8 | 3.0 | 70 (19-189) | — | ||
| Normal karotype | 153 | 8.2 (5.4-12.9) | 77 | 16 | 7 | 3.1 | 78 (19-196) | 68 | 83.7 | .019 |
| Abnormal karotype | 201 | 8.3 (5.2-11.9) | 77 | 14 | 9 | 2.9 | 62 (19-188) | 114 | 98.3 | — |
| Hypodiploid | 16 | 7.9 (5.7-10.0) | 68 | 19 | 13 | 4.3 | 76 (15-107) | 12 | 9.0 | .63 |
| Pseudodiploid | 124 | 7.8 (4.8-11.8) | 75 | 15 | 10 | 4.0 | 66 (21-233) | 67 | 72.2 | — |
| Hyperdiploid, 47-50 chrom. | 47 | 8.5 (5.4-13.2) | 78 | 13 | 9 | 2.1 | 60 (16-161) | 26 | 25.5 | — |
| Hyperdiploid, >50 chrom. | 14 | 8.5 (7.1-12.3) | 86 | 7 | 7 | 0.75 | 21 (11-71) | 9 | 7.3 | — |
| Any translocation | 122 | 7.8 (4.8-11.9) | 70 | 19 | 11 | 2.7 | 65 (20-189) | 66 | 70.1 | .43 |
| Any del chrom. | 91 | 8.5 (4.9-11.8) | 75 | 13 | 12 | 3.3 | 60 (20-199) | 57 | 64.9 | .14 |
| Any der chrom. | 51 | 9.8 (5.3-14.0) | 72 | 20 | 8 | 2.4 | 77 (14-202) | 35 | 25.7 | .037 |
| Any 14q11-13 abnormality | 43 | 8.2 (4.7-13.7) | 65 | 19 | 16 | 4.4 | 85 (25-391) | 19 | 27.0 | .08 |
| Del(6q) | 38 | 8.8 (5.0-11.3) | 76 | 11 | 13 | 4.4 | 75 (39-340) | 27 | 20.0 | .087 |
| +8 | 22 | 7.0 (4.2-12.9) | 86 | 14 | 0 | 1.8 | 56 (10-154) | 12 | 11.0 | .76 |
| Loss of 9p* | 32 | 9.0 (6.3-12.8) | 78 | 13 | 9 | 3.0 | 83 (26-219) | 16 | 18.3 | .56 |
| t(11;14) | 14 | 6.8 (4.1-11.8) | 72 | 7 | 21 | 2.5 | 407 (58-466) | 8 | 7.8 | .94 |
| t(10;14) | 12 | 7.5 (5.1-9.4) | 67 | 33 | 0 | 5.0 | 54 (14-130) | 3 | 9.7 | .024 |
| Loss of 5q† | 19 | 7.4 (4.5-11.1) | 63 | 26 | 11 | 3.8 | 19 (3-96) | 15 | 8.5 | .067 |
The expected outcome is the log-rank that is anticipated under the hypothesis that there is no difference in target population survival curves. The P values for specific abnormalities are compared to others with abnormal karyotypes.
Includes del(9p), der(9) with loss of 9p material, and −9.
Includes del(5q), der(5) with loss of 5q material, and −5.