An organizational heirarchy (top to bottom) has been used to present the data in this table. The first level of organization is based on previous therapy (0,<12, and >12 months). Within each therapy group the cases are organized according to karotype (UI, MM, MM+Δ13). Within the each karyotype group the TRI-FISH data is organized based on the extent of molecular deletion.

Ig heavy chain isotype and light chain.

Percent plasma cells in bone marrow aspirate.

Percent myeloma cells incorporating BrdU.

Months of prior therapy as of the sample data.

UI = uniformative metaphases; MM = numeric and structural abnormalities consistent with myeloma without chromosome 13 abnormalities; MM+D13 myeloma karyotype plus alterations in chromosome 13. Number preceding MM or MM+Δ13 = numer of chromosomes in cell.

TRI-FISH results. Eleven TRI-FISH probes (top of each column) ordered from centromere to telomere (left to right). Number of FISH signals = box color: 3 = white; 2 = stippled; 1 = gray; 0 = black; not analyzed = hatched; Numbers in box = percent of cells with given abnormality; Two numbers = percent with 0 signal/percent with 1signal. Case #5 and #39 are from the same patient on different dates.