Table 5.

Histologic and immunohistologic characteristics of the 7 cases of LPHD with diffuse growth pattern

Morphology of neoplastic cells  
•  L&H-cell features (100%)  
Immunophenotype of neoplastic cells  
• CD20 (100%) 
• CD79a (71%)  
• J-chain (67%) 
• EMA (86%)  
Immunohistologic features 
•  Neoplastic cells arranged in a vaguely nodular fashion (86%)  
•  Single small foci of small B cells (43%)  
•  Few scattered CD57+cells with focal condensation (43%) 
•  CD21+ follicular dendritic cells (0%) 
Morphology of neoplastic cells  
•  L&H-cell features (100%)  
Immunophenotype of neoplastic cells  
• CD20 (100%) 
• CD79a (71%)  
• J-chain (67%) 
• EMA (86%)  
Immunohistologic features 
•  Neoplastic cells arranged in a vaguely nodular fashion (86%)  
•  Single small foci of small B cells (43%)  
•  Few scattered CD57+cells with focal condensation (43%) 
•  CD21+ follicular dendritic cells (0%) 

LPHD, lymphocyte predominance Hodgkin's disease; EMA, epithelial membrane antigen.

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