Nonhematologic reinduction toxicity
| Toxicity . | Number of evaluable patients5-150 . | Number (percentage) with toxicity . |
|---|---|---|
| Infection5-151 | 143 | 72 (50%) |
| Low fibrinogen (≤ 50 mg/dL) | 127 | 32 (25%) |
| Hypoalbuminemia (≤ 2.5 g/L) | 142 | 29 (20%) |
| Mucositis (IV fluids needed) | 141 | 22 (16%) |
| Increased bilirubin (≥ 1.5 mg/dL) | 143 | 22 (15%) |
| Elevated ALT (≥ 150 U/L) | 143 | 13 (9%) |
| Weight loss (≥ 10%) | 143 | 9 (6%) |
| Toxicity . | Number of evaluable patients5-150 . | Number (percentage) with toxicity . |
|---|---|---|
| Infection5-151 | 143 | 72 (50%) |
| Low fibrinogen (≤ 50 mg/dL) | 127 | 32 (25%) |
| Hypoalbuminemia (≤ 2.5 g/L) | 142 | 29 (20%) |
| Mucositis (IV fluids needed) | 141 | 22 (16%) |
| Increased bilirubin (≥ 1.5 mg/dL) | 143 | 22 (15%) |
| Elevated ALT (≥ 150 U/L) | 143 | 13 (9%) |
| Weight loss (≥ 10%) | 143 | 9 (6%) |
IV = intravenous; ALT = alanine aminotransferase.
All patients were not fully evaluable for each toxicity.
Includes fever without identifiable source, documented bacterial or fungal sepsis, or localized serious infection (herpes stomatitis, fungal sinusitis, perirectal abscess). Four of these 72 patients died from sepsis (see text).