Threshold analyses
| Variable . | Reference case value . | Threshold level favoring ITI . | Comments . |
|---|---|---|---|
| Probability of success of ITI | 0.8 | > 0.26 | Range in literature 63-83% |
| Induction costs | $937,000 | < $2.6M | |
| Discount rate | 3% | < 9% | |
| Price FVIII | $1.11/U | < $1.98/U | |
| Price aPCC | $1.17/U | > $0.65/U | |
| Price pFVIII | $1.56/U | — | Not sensitive to price of pFVIII |
| Annual rate of minor bleeding episodes | 15 | > 4 |
| Variable . | Reference case value . | Threshold level favoring ITI . | Comments . |
|---|---|---|---|
| Probability of success of ITI | 0.8 | > 0.26 | Range in literature 63-83% |
| Induction costs | $937,000 | < $2.6M | |
| Discount rate | 3% | < 9% | |
| Price FVIII | $1.11/U | < $1.98/U | |
| Price aPCC | $1.17/U | > $0.65/U | |
| Price pFVIII | $1.56/U | — | Not sensitive to price of pFVIII |
| Annual rate of minor bleeding episodes | 15 | > 4 |
The threshold level for a given variable represents the level at which the preferred strategy shifts to ITI followed by conventional doses of FVIII from the indefinite use of alternative hemostatic agents.