Probabilities used in ITI model
| Success rate of ITI* | Complete response = 0.8 |
| Partial response = 0.05 | |
| Failure = 0.15 | |
| Likelihood of annual number of minor bleeding episodes | Low = 0.1 Average = 0.8 High = 0.1 |
| Success rate of hemostatic agents | |
| aPCC | 0.75 |
| pFVIII | 1.0 |
| Lifetime risk and rate of developing arthropathy | 0.75 over 15 y with inhibitor 0.75 over 20 y without inhibitor |
| Success rate of ITI* | Complete response = 0.8 |
| Partial response = 0.05 | |
| Failure = 0.15 | |
| Likelihood of annual number of minor bleeding episodes | Low = 0.1 Average = 0.8 High = 0.1 |
| Success rate of hemostatic agents | |
| aPCC | 0.75 |
| pFVIII | 1.0 |
| Lifetime risk and rate of developing arthropathy | 0.75 over 15 y with inhibitor 0.75 over 20 y without inhibitor |
Complete response indicates inhibitor titer not detected immunologically, and normalization of FVIII pharmacokinetics. Partial response indicates inhibitor titer of 5 BU. Failure indicates no response, inhibitor titer remains 25 BU.