CD26/DPP IV processes the NH2-terminus of LD78β but not LD78α or MIP-1β
| Chemokine . | NH2-terminal sequence . | |
|---|---|---|
| Untreated chemokine | After CD26 treatment | |
| LD78α | ASLAADTPTACC | ASLAADTPTACC |
| LD78β | AP-LA-ADTPTACC | LAADTPTACC |
| MIP-1β | AP-MGSDPPTACC | APMGSDPPTACC |
| Chemokine . | NH2-terminal sequence . | |
|---|---|---|
| Untreated chemokine | After CD26 treatment | |
| LD78α | ASLAADTPTACC | ASLAADTPTACC |
| LD78β | AP-LA-ADTPTACC | LAADTPTACC |
| MIP-1β | AP-MGSDPPTACC | APMGSDPPTACC |
Chemokines were treated overnight with CD26/DPP IV, and the NH2-terminal sequence was determined by automated Edman degradation. The expected cleavage sites13 from the known consensus sequence for CD26/DPP IV are indicated with a hyphen (-).