Mice infused with 8-fold more microparticles showed no alteration in the wet:dry ratio or total myeloperoxidase activity in the lungs at 6 hours compared with mice injected with PBS alone
| . | Wet:Dry . | Myeloperoxidase . |
|---|---|---|
| Microparticles | 4.46 ± 0.26 | 0.65 ± 0.15 |
| PBS | 4.51 ± 0.12 | 0.59 ± 0.10 |
| . | Wet:Dry . | Myeloperoxidase . |
|---|---|---|
| Microparticles | 4.46 ± 0.26 | 0.65 ± 0.15 |
| PBS | 4.51 ± 0.12 | 0.59 ± 0.10 |
WT and uPA−/− mice were injected with either an 8-fold concentrated suspension of unlabeled fibrin microparticles (relative to 125I-microparticles used in other experiments) or PBS. Six hours later, the animals were sacrificed, and the lungs were isolated and washed. The wet:dry ratio and the myeloperoxidase activity were measured as described in “Materials and methods.” The results shown represent the mean plus or minus SEM of 6 mice injected with fibrin microparticles and 4 mice injected with PBS.