Nonhematologic adverse events
| Event . | All patients (n = 59) . | Unknown . | Grade I . | Grade II . | Grade III . | Grade IV . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N . | % . | N . | % . | N . | % . | N . | % . | N . | % . | N . | % . | |
| Fever | 31 | 53 | 0 | 0 | 11 | 19 | 20 | 34 | 0 | 0 | 0 | 0 |
| Asthenia | 20 | 34 | 0 | 0 | 19 | 32 | 1 | 2 | 0 | 0 | 0 | 0 |
| Nausea | 20 | 34 | 0 | 0 | 18 | 31 | 1 | 2 | 1 | 2 | 0 | 0 |
| Chills | 17 | 29 | 0 | 0 | 10 | 17 | 3 | 5 | 4 | 7 | 0 | 0 |
| Infection | 13 | 22 | 2 | 3 | 9 | 15 | 2 | 3 | 0 | 0 | 0 | 0 |
| Arthralgia | 13 | 22 | 1 | 2 | 11 | 19 | 1 | 2 | 0 | 0 | 0 | 0 |
| Rash | 11 | 19 | 1 | 2 | 7 | 12 | 3 | 5 | 0 | 0 | 0 | 0 |
| Pain | 9 | 15 | 0 | 0 | 9 | 15 | 0 | 0 | 0 | 0 | 0 | 0 |
| Vomiting | 8 | 14 | 0 | 0 | 6 | 10 | 1 | 2 | 1 | 2 | 0 | 0 |
| Urticaria | 8 | 14 | 0 | 0 | 3 | 5 | 5 | 8 | 0 | 0 | 0 | 0 |
| Headache | 7 | 12 | 0 | 0 | 6 | 10 | 1 | 2 | 0 | 0 | 0 | 0 |
| Myalgia | 7 | 12 | 1 | 2 | 6 | 10 | 0 | 0 | 0 | 0 | 0 | 0 |
| Diarrhea | 6 | 10 | 0 | 0 | 5 | 8 | 0 | 0 | 1 | 2 | 0 | 0 |
| Pharyngitis | 6 | 10 | 0 | 0 | 6 | 10 | 0 | 0 | 0 | 0 | 0 | 0 |
| Pruritus | 6 | 10 | 0 | 0 | 5 | 8 | 1 | 2 | 0 | 0 | 0 | 0 |
| Dizziness | 5 | 8 | 1 | 2 | 3 | 5 | 0 | 0 | 1 | 2 | 0 | 0 |
| Urinary tract infection | 5 | 8 | 0 | 0 | 3 | 5 | 2 | 3 | 0 | 0 | 0 | 0 |
| Abdominal pain | 4 | 7 | 0 | 0 | 4 | 7 | 0 | 0 | 0 | 0 | 0 | 0 |
| Serum sickness | 4 | 7 | 1 | 2 | 0 | 0 | 0 | 0 | 3 | 5 | 0 | 0 |
| Anorexia | 4 | 7 | 1 | 2 | 3 | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
| Injection site reaction | 3 | 5 | 1 | 2 | 1 | 2 | 1 | 2 | 0 | 0 | 0 | 0 |
| Constipation | 3 | 5 | 0 | 0 | 3 | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
| Gastritis | 3 | 5 | 0 | 0 | 2 | 3 | 1 | 2 | 0 | 0 | 0 | 0 |
| Hypothyroidism | 3 | 5 | 0 | 0 | 0 | 0 | 3 | 5 | 0 | 0 | 0 | 0 |
| Paresthesia | 3 | 5 | 3 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Cough increased | 3 | 5 | 0 | 0 | 3 | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
| Rhinitis | 3 | 5 | 0 | 0 | 2 | 3 | 1 | 2 | 0 | 0 | 0 | 0 |
| Sweating | 3 | 5 | 0 | 0 | 1 | 2 | 2 | 3 | 0 | 0 | 0 | 0 |
| Conjunctivitis | 3 | 5 | 0 | 0 | 3 | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
| Event . | All patients (n = 59) . | Unknown . | Grade I . | Grade II . | Grade III . | Grade IV . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N . | % . | N . | % . | N . | % . | N . | % . | N . | % . | N . | % . | |
| Fever | 31 | 53 | 0 | 0 | 11 | 19 | 20 | 34 | 0 | 0 | 0 | 0 |
| Asthenia | 20 | 34 | 0 | 0 | 19 | 32 | 1 | 2 | 0 | 0 | 0 | 0 |
| Nausea | 20 | 34 | 0 | 0 | 18 | 31 | 1 | 2 | 1 | 2 | 0 | 0 |
| Chills | 17 | 29 | 0 | 0 | 10 | 17 | 3 | 5 | 4 | 7 | 0 | 0 |
| Infection | 13 | 22 | 2 | 3 | 9 | 15 | 2 | 3 | 0 | 0 | 0 | 0 |
| Arthralgia | 13 | 22 | 1 | 2 | 11 | 19 | 1 | 2 | 0 | 0 | 0 | 0 |
| Rash | 11 | 19 | 1 | 2 | 7 | 12 | 3 | 5 | 0 | 0 | 0 | 0 |
| Pain | 9 | 15 | 0 | 0 | 9 | 15 | 0 | 0 | 0 | 0 | 0 | 0 |
| Vomiting | 8 | 14 | 0 | 0 | 6 | 10 | 1 | 2 | 1 | 2 | 0 | 0 |
| Urticaria | 8 | 14 | 0 | 0 | 3 | 5 | 5 | 8 | 0 | 0 | 0 | 0 |
| Headache | 7 | 12 | 0 | 0 | 6 | 10 | 1 | 2 | 0 | 0 | 0 | 0 |
| Myalgia | 7 | 12 | 1 | 2 | 6 | 10 | 0 | 0 | 0 | 0 | 0 | 0 |
| Diarrhea | 6 | 10 | 0 | 0 | 5 | 8 | 0 | 0 | 1 | 2 | 0 | 0 |
| Pharyngitis | 6 | 10 | 0 | 0 | 6 | 10 | 0 | 0 | 0 | 0 | 0 | 0 |
| Pruritus | 6 | 10 | 0 | 0 | 5 | 8 | 1 | 2 | 0 | 0 | 0 | 0 |
| Dizziness | 5 | 8 | 1 | 2 | 3 | 5 | 0 | 0 | 1 | 2 | 0 | 0 |
| Urinary tract infection | 5 | 8 | 0 | 0 | 3 | 5 | 2 | 3 | 0 | 0 | 0 | 0 |
| Abdominal pain | 4 | 7 | 0 | 0 | 4 | 7 | 0 | 0 | 0 | 0 | 0 | 0 |
| Serum sickness | 4 | 7 | 1 | 2 | 0 | 0 | 0 | 0 | 3 | 5 | 0 | 0 |
| Anorexia | 4 | 7 | 1 | 2 | 3 | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
| Injection site reaction | 3 | 5 | 1 | 2 | 1 | 2 | 1 | 2 | 0 | 0 | 0 | 0 |
| Constipation | 3 | 5 | 0 | 0 | 3 | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
| Gastritis | 3 | 5 | 0 | 0 | 2 | 3 | 1 | 2 | 0 | 0 | 0 | 0 |
| Hypothyroidism | 3 | 5 | 0 | 0 | 0 | 0 | 3 | 5 | 0 | 0 | 0 | 0 |
| Paresthesia | 3 | 5 | 3 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Cough increased | 3 | 5 | 0 | 0 | 3 | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
| Rhinitis | 3 | 5 | 0 | 0 | 2 | 3 | 1 | 2 | 0 | 0 | 0 | 0 |
| Sweating | 3 | 5 | 0 | 0 | 1 | 2 | 2 | 3 | 0 | 0 | 0 | 0 |
| Conjunctivitis | 3 | 5 | 0 | 0 | 3 | 5 | 0 | 0 | 0 | 0 | 0 | 0 |
All adverse events that occurred in at least 5% of patients.