Response rates by patient subgroup
| . | No. of patients . | Response . | Complete response . | ||
|---|---|---|---|---|---|
| % (N) . | P value . | % (N) . | P value . | ||
| Age | |||||
| >60 | 10 | 60 (6) | 20 (2) | ||
| ≤60 | 49 | 73 (36) | .391 | 37 (18) | .308 |
| Histology | |||||
| Low grade | 28 | 86 (24) | 46 (13) | ||
| Low transformed | 14 | 79 (11) | 50 (7) | ||
| De novo intermediate/high | 17 | 41 (7) | .005 | 0 (0) | .002 |
| Lactate dehydrogenase (LDH) | |||||
| Elevated | 30 | 57 (17) | 17 (5) | ||
| Normal/low | 29 | 86 (25) | .012 | 52 (15) | 0.005 |
| Bulky disease | |||||
| No | 38 | 82 (31) | 37 (14) | ||
| Yes | 21 | 52 (11) | .018 | 29 (6) | .521 |
| Prior bone marrow transplant | |||||
| No | 45 | 78 (35) | 33 (15) | ||
| Yes | 14 | 50 (7) | .045 | 36 (5) | .869 |
| Stage of disease | |||||
| I/II | 7 | 57 (4) | 29 (2) | ||
| III/IV | 52 | 73 (38) | .382 | 35 (18) | .751 |
| Prior chemotherapies (No.) | |||||
| 1-2 | 16 | 69 (11) | 31 (5) | ||
| ≥3 | 43 | 72 (31) | .801 | 35 (15) | .793 |
| Last chemotherapy | |||||
| No response | 28 | 75 (21) | 29 (8) | ||
| Response | 30 | 70 (21) | .670 | 40 (12) | .360 |
| . | No. of patients . | Response . | Complete response . | ||
|---|---|---|---|---|---|
| % (N) . | P value . | % (N) . | P value . | ||
| Age | |||||
| >60 | 10 | 60 (6) | 20 (2) | ||
| ≤60 | 49 | 73 (36) | .391 | 37 (18) | .308 |
| Histology | |||||
| Low grade | 28 | 86 (24) | 46 (13) | ||
| Low transformed | 14 | 79 (11) | 50 (7) | ||
| De novo intermediate/high | 17 | 41 (7) | .005 | 0 (0) | .002 |
| Lactate dehydrogenase (LDH) | |||||
| Elevated | 30 | 57 (17) | 17 (5) | ||
| Normal/low | 29 | 86 (25) | .012 | 52 (15) | 0.005 |
| Bulky disease | |||||
| No | 38 | 82 (31) | 37 (14) | ||
| Yes | 21 | 52 (11) | .018 | 29 (6) | .521 |
| Prior bone marrow transplant | |||||
| No | 45 | 78 (35) | 33 (15) | ||
| Yes | 14 | 50 (7) | .045 | 36 (5) | .869 |
| Stage of disease | |||||
| I/II | 7 | 57 (4) | 29 (2) | ||
| III/IV | 52 | 73 (38) | .382 | 35 (18) | .751 |
| Prior chemotherapies (No.) | |||||
| 1-2 | 16 | 69 (11) | 31 (5) | ||
| ≥3 | 43 | 72 (31) | .801 | 35 (15) | .793 |
| Last chemotherapy | |||||
| No response | 28 | 75 (21) | 29 (8) | ||
| Response | 30 | 70 (21) | .670 | 40 (12) | .360 |