Translocations involving the immunoglobulin loci
| Disease . | Frequency . | Involved genes . |
|---|---|---|
| BCP-ALL | ||
| t(5;14)(q31;q32) | <1% | IL3 |
| t(1;14)(q21;q32) | <1% | BCL9 |
| B-NHL | ||
| Burkitt's lymphoma | ||
| t(8;14)(q24;q32) | 100% | MYC |
| Follicular lymphoma | ||
| t(14;18)(q32;q21) | ∼80% | BCL2 |
| t(1;22)(q22;q11) | <1% | FCGRIIB |
| Mantle cell lymphoma | ||
| t(11;14)(q13;q32) | >95% | Cyclin D1 |
| DLCL | ||
| t(14;18)(q21;q32) | 20% | BCL2 |
| t(8;14)(q24;q32) | 10% | MYC |
| t(3;14)(q27;q32) | 5-10% | BCL6 |
| t(14;15)(q32;q11-13) | <1% | BCL8 |
| t(10;14)(q24;q32) | <1% | NFKB2 |
| Marginal zone lymphoma | ||
| Lymphoplasmacytoid lymphoma | ||
| t(9;14)(p13)(q32) | 50% | PAX5 |
| MALT | ||
| t(1;14)(p22;q32) | <5% | BCL10 |
| SLVL | ||
| t(7;14)(q21;q32), t(2;7)(p12;q21) | <5% | CDK6 |
| Others | ||
| t(11;14)(q23;q32) | <1% | PAFAH2 |
| t(11;14)(q23;q32) | <1% | RCK |
| t(12;14)(q24;q32) | <1% | BCL7A |
| t(12;22)(p13;q11) | <1% | Cyclin D2 |
| CLL | ||
| t(14;18)(q32;q21) | 1-2% | BCL2 |
| t(14;19)(q32;q13) | <1% | BCL3 |
| t(2;14)(p13;q32) | <1% | BCL11A |
| Myeloma | ||
| t(11;14)(q13;q32) | 20-25% | Cyclin D1 |
| t(4;14)(p16;q32) | 20-25% | FGFR3 |
| MMSET | ||
| t(6;14)(p25;q32) | ∼20% | IRF4 |
| t(14;16)(q32;q23) | 20-25% | C-MAF |
| t(1;14)(q21;q32) | <5% | MUM2/3 |
| Disease . | Frequency . | Involved genes . |
|---|---|---|
| BCP-ALL | ||
| t(5;14)(q31;q32) | <1% | IL3 |
| t(1;14)(q21;q32) | <1% | BCL9 |
| B-NHL | ||
| Burkitt's lymphoma | ||
| t(8;14)(q24;q32) | 100% | MYC |
| Follicular lymphoma | ||
| t(14;18)(q32;q21) | ∼80% | BCL2 |
| t(1;22)(q22;q11) | <1% | FCGRIIB |
| Mantle cell lymphoma | ||
| t(11;14)(q13;q32) | >95% | Cyclin D1 |
| DLCL | ||
| t(14;18)(q21;q32) | 20% | BCL2 |
| t(8;14)(q24;q32) | 10% | MYC |
| t(3;14)(q27;q32) | 5-10% | BCL6 |
| t(14;15)(q32;q11-13) | <1% | BCL8 |
| t(10;14)(q24;q32) | <1% | NFKB2 |
| Marginal zone lymphoma | ||
| Lymphoplasmacytoid lymphoma | ||
| t(9;14)(p13)(q32) | 50% | PAX5 |
| MALT | ||
| t(1;14)(p22;q32) | <5% | BCL10 |
| SLVL | ||
| t(7;14)(q21;q32), t(2;7)(p12;q21) | <5% | CDK6 |
| Others | ||
| t(11;14)(q23;q32) | <1% | PAFAH2 |
| t(11;14)(q23;q32) | <1% | RCK |
| t(12;14)(q24;q32) | <1% | BCL7A |
| t(12;22)(p13;q11) | <1% | Cyclin D2 |
| CLL | ||
| t(14;18)(q32;q21) | 1-2% | BCL2 |
| t(14;19)(q32;q13) | <1% | BCL3 |
| t(2;14)(p13;q32) | <1% | BCL11A |
| Myeloma | ||
| t(11;14)(q13;q32) | 20-25% | Cyclin D1 |
| t(4;14)(p16;q32) | 20-25% | FGFR3 |
| MMSET | ||
| t(6;14)(p25;q32) | ∼20% | IRF4 |
| t(14;16)(q32;q23) | 20-25% | C-MAF |
| t(1;14)(q21;q32) | <5% | MUM2/3 |
IG translocations are shown here classified by disease subtype together with their frequency of occurrence in that disease and the gene deregulated by the translocation. In some cases, variant translocations involving the IG light chain loci are also found; these have generally been omitted for clarity.