Changes in leukocyte counts and differential after LPS administration to healthy subjects
| Time point (h) . | Leukocytes . | Granulocytes . | Monocytes . | Lymphocytes . |
|---|---|---|---|---|
| −0.5 | 5.2 ± 1.1 | 2.9 ± 0.7 | 0.5 ± 0.1 | 1.6 ± 0.3 |
| +0.5 | 4.9 ± 0.9 | 2.9 ± 0.7 | 0.3 ± 0.1 | 1.5 ± 0.2 |
| +1 | 2.0 ± 0.3 | 0.9 ± 0.3 | 0.05 ± 0.02 | 0.9 ± 0.1 |
| +2 | 5.2 ± 1.4 | 4.4 ± 1.4 | 0.05 ± 0.02 | 0.7 ± 0.1 |
| +3 | 4.9 ± 1.3 | 4.5 ± 1.3 | 0.03 ± 0.02 | 0.4 ± 0.1 |
| +4 | 7.8 ± 1.5 | 7.4 ± 1.4 | 0.07 ± 0.04 | 0.3 ± 0.1 |
| +6 | 11.1 ± 1.4 | 10.5 ± 1.4 | 0.2 ± 0.1 | 0.4 ± 0.1 |
| +8 | 13.0 ± 2.9 | 12.0 ± 2.9 | 0.5 ± 0.1 | 0.5 ± 0.1 |
| +24 | 9.7 ± 2.7 | 7.1 ± 2.6 | 0.6 ± 0.1 | 1.7 ± 0.3 |
| Time point (h) . | Leukocytes . | Granulocytes . | Monocytes . | Lymphocytes . |
|---|---|---|---|---|
| −0.5 | 5.2 ± 1.1 | 2.9 ± 0.7 | 0.5 ± 0.1 | 1.6 ± 0.3 |
| +0.5 | 4.9 ± 0.9 | 2.9 ± 0.7 | 0.3 ± 0.1 | 1.5 ± 0.2 |
| +1 | 2.0 ± 0.3 | 0.9 ± 0.3 | 0.05 ± 0.02 | 0.9 ± 0.1 |
| +2 | 5.2 ± 1.4 | 4.4 ± 1.4 | 0.05 ± 0.02 | 0.7 ± 0.1 |
| +3 | 4.9 ± 1.3 | 4.5 ± 1.3 | 0.03 ± 0.02 | 0.4 ± 0.1 |
| +4 | 7.8 ± 1.5 | 7.4 ± 1.4 | 0.07 ± 0.04 | 0.3 ± 0.1 |
| +6 | 11.1 ± 1.4 | 10.5 ± 1.4 | 0.2 ± 0.1 | 0.4 ± 0.1 |
| +8 | 13.0 ± 2.9 | 12.0 ± 2.9 | 0.5 ± 0.1 | 0.5 ± 0.1 |
| +24 | 9.7 ± 2.7 | 7.1 ± 2.6 | 0.6 ± 0.1 | 1.7 ± 0.3 |
Data shown are mean ± SEM. Values refer to number of cells ×103/μL. Time points refer to intravenous LPS injection (t = 0). LPS, lipopolysaccharide.