Effects of the GR antagonist RU486 on tumor formation in SCID mice
| − RU486 . | + RU486 . | ||||
|---|---|---|---|---|---|
| Size of s.c. Masses, cm3 . | Mice, n/total . | % . | Size of s.c. Masses, cm3 . | Mice, n/total . | % . |
| >4 | 12/12 | 100 | >4 | 3/12 | 25 |
| ≤4 | — | — | ≤4 | 4/12* | 33.3 |
| None | — | — | None | 5/12 | 41.7 |
| − RU486 . | + RU486 . | ||||
|---|---|---|---|---|---|
| Size of s.c. Masses, cm3 . | Mice, n/total . | % . | Size of s.c. Masses, cm3 . | Mice, n/total . | % . |
| >4 | 12/12 | 100 | >4 | 3/12 | 25 |
| ≤4 | — | — | ≤4 | 4/12* | 33.3 |
| None | — | — | None | 5/12 | 41.7 |
The size of tumor masses was evaluated 35 days after s.c. inoculation of 10 × 106 DAA-3 cells persistently growth-arrested in vitro by a 7-day treatment with 10−5mol/L 13-cis-RA.
Indicates that these animals carried masses markedly smaller than 4 cm3 (between 0.04 cm3 and 0.5 cm3). Mice treated with RU486 developed significantly fewer s.c. masses greater than 4 cm3 (P = .0003, 2-tailed Fisher exact test).