Comparison of rectal tissue and blood HIV RNA and CD4ζ persistence
| Patient . | Time point, d . | HIV RNA . | CD4ζ . | |||
|---|---|---|---|---|---|---|
| Tissue (log copies/μg RNA) . | Plasma (log copies/mL) . | Blood (log copies/106 PBMCs) . | Bulk tissue (log copies/106 cells) . | LPLs (log copies/106 cells) . | ||
| S201 | Preinfusion | 4.04 | 3.13 | 0 | 0 | 0 |
| (+IL-2) | 3 | 2.83 | 3.06 | 4.23 | 1.88 | 0 |
| 7 | NA | 2.81 | 4.55 | 3.04 | 0 | |
| 14 | 2.90 | 3.01 | 4.35 | 3.15 | 0.85 | |
| 365 | NA | NA | NA | NA | NA | |
| Q202 | Preinfusion | 2.16 | 4.14 | 0 | 0 | 0 |
| (−IL-2) | 3 | 2.14 | NA | 4.37 | 1.38 | 1.67 |
| 7 | 2.24 | 4.60 | NA | 2.41 | 1.62 | |
| 14 | 1.63 | 4.03 | 4.07 | 1.85 | 0 | |
| 365 | NA | NA | 3.08 | 0 | NA | |
| E207 | Preinfusion | 2.62 | 4.42 | 0 | 0 | 3.36 |
| (−IL-2) | 3 | 2.15 | 4.68 | 4.28 | 2.84 | 2.08 |
| 7 | 2.57 | 4.65 | NA | 2.91 | 2.36 | |
| 14 | 2.09 | 5.24 | 3.20 | 2.94 | 2.77 | |
| 365 | NA | NA | 3.42 | 2.44 | NA | |
| U213 | Preinfusion | 2.72 | 5.10 | 0 | 0 | 0 |
| (+IL-2) | 3 | 3.13 | 5.08 | 4.26 | 2.63 | 0 |
| 7 | 2.87 | 4.23 | 4.03 | 3.55 | 2.18 | |
| 14 | 2.20 | 4.79 | 3.59 | 1.68 | 0 | |
| 365 | NA | NA | NA | NA | NA | |
| D212 | Preinfusion | 3.52 | 4.61 | 0 | 0 | 0 |
| (−IL-2) | 3 | 2.56 | 4.98 | 4.16 | 2.60 | 3.20 |
| 7 | 2.26 | 4.92 | NA | 2.78 | 2.47 | |
| 14 | 3.51 | 4.84 | 3.78 | 2.86 | 3.41 | |
| 365 | NA | NA | 2.88 | 2.24 | NA | |
| Mean | Preinfusion | 3.10 | 4.33 | 0 | 0 | 0.67 |
| 3 | 2.60 | 4.45 | 4.26 | 2.27 | 1.39 | |
| 7 | 2.48 | 4.24 | 4.29 | 2.94 | 1.73 | |
| 14 | 2.47 | 4.38 | 3.80 | 2.50 | 1.41 | |
| Composite mean (days 3-14) | 2.52 | 4.36 | 4.10 | 2.60 | 1.30 | |
| Patient . | Time point, d . | HIV RNA . | CD4ζ . | |||
|---|---|---|---|---|---|---|
| Tissue (log copies/μg RNA) . | Plasma (log copies/mL) . | Blood (log copies/106 PBMCs) . | Bulk tissue (log copies/106 cells) . | LPLs (log copies/106 cells) . | ||
| S201 | Preinfusion | 4.04 | 3.13 | 0 | 0 | 0 |
| (+IL-2) | 3 | 2.83 | 3.06 | 4.23 | 1.88 | 0 |
| 7 | NA | 2.81 | 4.55 | 3.04 | 0 | |
| 14 | 2.90 | 3.01 | 4.35 | 3.15 | 0.85 | |
| 365 | NA | NA | NA | NA | NA | |
| Q202 | Preinfusion | 2.16 | 4.14 | 0 | 0 | 0 |
| (−IL-2) | 3 | 2.14 | NA | 4.37 | 1.38 | 1.67 |
| 7 | 2.24 | 4.60 | NA | 2.41 | 1.62 | |
| 14 | 1.63 | 4.03 | 4.07 | 1.85 | 0 | |
| 365 | NA | NA | 3.08 | 0 | NA | |
| E207 | Preinfusion | 2.62 | 4.42 | 0 | 0 | 3.36 |
| (−IL-2) | 3 | 2.15 | 4.68 | 4.28 | 2.84 | 2.08 |
| 7 | 2.57 | 4.65 | NA | 2.91 | 2.36 | |
| 14 | 2.09 | 5.24 | 3.20 | 2.94 | 2.77 | |
| 365 | NA | NA | 3.42 | 2.44 | NA | |
| U213 | Preinfusion | 2.72 | 5.10 | 0 | 0 | 0 |
| (+IL-2) | 3 | 3.13 | 5.08 | 4.26 | 2.63 | 0 |
| 7 | 2.87 | 4.23 | 4.03 | 3.55 | 2.18 | |
| 14 | 2.20 | 4.79 | 3.59 | 1.68 | 0 | |
| 365 | NA | NA | NA | NA | NA | |
| D212 | Preinfusion | 3.52 | 4.61 | 0 | 0 | 0 |
| (−IL-2) | 3 | 2.56 | 4.98 | 4.16 | 2.60 | 3.20 |
| 7 | 2.26 | 4.92 | NA | 2.78 | 2.47 | |
| 14 | 3.51 | 4.84 | 3.78 | 2.86 | 3.41 | |
| 365 | NA | NA | 2.88 | 2.24 | NA | |
| Mean | Preinfusion | 3.10 | 4.33 | 0 | 0 | 0.67 |
| 3 | 2.60 | 4.45 | 4.26 | 2.27 | 1.39 | |
| 7 | 2.48 | 4.24 | 4.29 | 2.94 | 1.73 | |
| 14 | 2.47 | 4.38 | 3.80 | 2.50 | 1.41 | |
| Composite mean (days 3-14) | 2.52 | 4.36 | 4.10 | 2.60 | 1.30 | |
PBMCs indicates peripheral blood mononuclear cells; LPLs, lamina propria lymphocytes; NA, data not available: IL-2, interleukin 2.