Relation between TEL/AML1 and in vitro drug resistance in 139 patients with B-lineage childhood ALL
| Drug . | TEL/AML1-negative median (25th-75th) . | TEL/AML1-positive median (25th-75th) . | P . |
|---|---|---|---|
| Prednisolone | 1.94 (0.30-24.7) | 0.43 (0.06-246) | .297 |
| Dexamethasone | 0.07 (0.03-4.11) | 0.06 (0.01-2.30) | .324 |
| Vincristine | 0.50 (0.16-1.52) | 0.72 (0.57-1.80) | .011 |
| L-Asparaginase | 0.31 (0.01-1.28) | 0.05 (0.01-0.38) | .029 |
| Daunorubicin | 0.09 (0.06-0.23) | 0.10 (0.07-0.20) | .461 |
| 6-Thioguanine | 6.03 (3.23-8.41) | 5.13 (3.45-7.99) | .314 |
| Cytarabine | 0.38 (0.15-1.14) | 0.59 (0.42-1.49) | .014 |
| Etoposide | 1.23 (0.54-2.50) | 1.53 (0.71-2.55) | .413 |
| Ifosfamide | 2.34 (0.83-5.16) | 3.29 (2.16-4.20) | .113 |
| Drug . | TEL/AML1-negative median (25th-75th) . | TEL/AML1-positive median (25th-75th) . | P . |
|---|---|---|---|
| Prednisolone | 1.94 (0.30-24.7) | 0.43 (0.06-246) | .297 |
| Dexamethasone | 0.07 (0.03-4.11) | 0.06 (0.01-2.30) | .324 |
| Vincristine | 0.50 (0.16-1.52) | 0.72 (0.57-1.80) | .011 |
| L-Asparaginase | 0.31 (0.01-1.28) | 0.05 (0.01-0.38) | .029 |
| Daunorubicin | 0.09 (0.06-0.23) | 0.10 (0.07-0.20) | .461 |
| 6-Thioguanine | 6.03 (3.23-8.41) | 5.13 (3.45-7.99) | .314 |
| Cytarabine | 0.38 (0.15-1.14) | 0.59 (0.42-1.49) | .014 |
| Etoposide | 1.23 (0.54-2.50) | 1.53 (0.71-2.55) | .413 |
| Ifosfamide | 2.34 (0.83-5.16) | 3.29 (2.16-4.20) | .113 |
Median LC50 values for TEL/AML1-negative (n = 90) versus TEL/AML1-positive patients (n = 49). All LC50values are expressed as μg/mL, except for L-asparaginase (IU/mL).P values were determined by the Mann-Whitney U test.