Frequencies of B-lineage cells among BM lymphoid cells in XLA patients and healthy controls of various ages
| Subjects . | μ−SL++ (pro-B cells), % . | Percentage of each B-lineage cell among BM lymphoid cells . | |||||
|---|---|---|---|---|---|---|---|
| μlowSL++ (pre-B1a cells), % . | μlowSL+ (pre-B1b cells), % . | μlowSL− (pre-B2 cells), % . | μhighSL− (B cells), % . | ||||
| XLA patients, n = 13 | 14.7 ± 7.43-150 | 3.0 ± 1.93-151 | 1.0 ± 0.63-152 | 0.6 ± 0.53-153 | 0.3 ± 0.33-153 | ||
| Infants, n = 10 | 6.1 ± 1.0 | 8.4 ± 2.5 | 14.3 ± 6.4 | 24.3 ± 4.7 | 16.7 ± 5.4 | ||
| Children, n = 10 | 5.2 ± 2.5 | 5.6 ± 1.8 | 9.1 ± 3.5 | 15.6 ± 7.1 | 15.1 ± 5.9 | ||
| Adults, n = 5 | 1.7 ± 0.6 | 0.9 ± 0.3 | 1.8 ± 1.1 | 5.6 ± 1.2 | 10.3 ± 3.6 | ||
| Subjects . | μ−SL++ (pro-B cells), % . | Percentage of each B-lineage cell among BM lymphoid cells . | |||||
|---|---|---|---|---|---|---|---|
| μlowSL++ (pre-B1a cells), % . | μlowSL+ (pre-B1b cells), % . | μlowSL− (pre-B2 cells), % . | μhighSL− (B cells), % . | ||||
| XLA patients, n = 13 | 14.7 ± 7.43-150 | 3.0 ± 1.93-151 | 1.0 ± 0.63-152 | 0.6 ± 0.53-153 | 0.3 ± 0.33-153 | ||
| Infants, n = 10 | 6.1 ± 1.0 | 8.4 ± 2.5 | 14.3 ± 6.4 | 24.3 ± 4.7 | 16.7 ± 5.4 | ||
| Children, n = 10 | 5.2 ± 2.5 | 5.6 ± 1.8 | 9.1 ± 3.5 | 15.6 ± 7.1 | 15.1 ± 5.9 | ||
| Adults, n = 5 | 1.7 ± 0.6 | 0.9 ± 0.3 | 1.8 ± 1.1 | 5.6 ± 1.2 | 10.3 ± 3.6 | ||
The frequencies are given as the mean plus or minus SD. Based on the data in Table 3, the relative frequencies of individual B-lineage cells among BM lymphoid cells were calculated as follows: their percentages within the total B-lineage cells multiplied by the percentages of total B-lineage cells in BM lymphoid cells divided by 100.
Significantly increased when compared with infants (P < .01), children (P < .01), and adults (P < .002).
Significantly reduced when compared with infants (P < .0001) and children (P < .01).
Significantly reduced when compared with infants (P < .0001), children (P < .0001), and adults (P < .05).
Significantly reduced when compared with infants (P < .0001), children (P < .0001), and adults (P < .0001).