Percentage of B-lineage cells in BM samples of XLA patients and healthy controls of various ages
| Subjects . | B-lineage cells in BM lymphoid cells, total % . | Percentage of cell types within B-lineage cells . | ||||||
|---|---|---|---|---|---|---|---|---|
| μ−SL++ (pro-B cells), % . | μlowSL++ (pre-B1a cells), % . | μlowSL+ (pre-B1b cells), % . | μlowSL− (pre-B2 cells), % . | μhighSL− (B cells), % . | ||||
| XLA patients, n = 13 | 19.7 ± 9.54-150 | 74.4 ± 10.14-151 | 14.5 ± 5.3‡ | 4.9 ± 2.74-153 | 3.3 ± 2.74-155 | 1.9 ± 1.84-155 | ||
| Infants, n = 10 | 70.8 ± 12.6 | 8.7 ± 2.3 | 11.9 ± 3.0 | 19.7 ± 5.9 | 34.5 ± 4.7 | 24.0 ± 7.6 | ||
| Children, n = 10 | 50.7 ± 11.8 | 10.8 ± 6.7 | 10.9 ± 3.0 | 17.6 ± 4.6 | 29.5 ± 8.1 | 30.6 ± 15.2 | ||
| Adults, n = 5 | 20.3 ± 3.3 | 7.9 ± 3.1 | 4.4 ± 1.4 | 9.3 ± 4.8 | 28.1 ± 5.5 | 49.6 ± 9.4 | ||
| Subjects . | B-lineage cells in BM lymphoid cells, total % . | Percentage of cell types within B-lineage cells . | ||||||
|---|---|---|---|---|---|---|---|---|
| μ−SL++ (pro-B cells), % . | μlowSL++ (pre-B1a cells), % . | μlowSL+ (pre-B1b cells), % . | μlowSL− (pre-B2 cells), % . | μhighSL− (B cells), % . | ||||
| XLA patients, n = 13 | 19.7 ± 9.54-150 | 74.4 ± 10.14-151 | 14.5 ± 5.3‡ | 4.9 ± 2.74-153 | 3.3 ± 2.74-155 | 1.9 ± 1.84-155 | ||
| Infants, n = 10 | 70.8 ± 12.6 | 8.7 ± 2.3 | 11.9 ± 3.0 | 19.7 ± 5.9 | 34.5 ± 4.7 | 24.0 ± 7.6 | ||
| Children, n = 10 | 50.7 ± 11.8 | 10.8 ± 6.7 | 10.9 ± 3.0 | 17.6 ± 4.6 | 29.5 ± 8.1 | 30.6 ± 15.2 | ||
| Adults, n = 5 | 20.3 ± 3.3 | 7.9 ± 3.1 | 4.4 ± 1.4 | 9.3 ± 4.8 | 28.1 ± 5.5 | 49.6 ± 9.4 | ||
The percentages are given as the mean plus or minus SD. The B-lineage cells were assessed as described in the footnotes of Table 2.
Significantly reduced when compared with infants (P < .0001) and children (P < .0001), but not with adults.
Markedly increased when compared with infants (P < .0001), children (P < .0001), and adults (P < .0001).
Not significantly different from infants and children.
Significantly reduced when compared with infants (P < .0001), children (P < .0001), and adults (P < .03).
Extremely lower when compared with infants (P < .0001), children (P < .0001), and adults (P < .0001).