Characteristics of T-cell lines
| Cell line . | Origin . | IL-2 dependency* . | HTLV-I provirus . | HTLV-I mRNA† . | Tax protein† . | JunD mRNA† . | AP-1 DNA binding† . |
|---|---|---|---|---|---|---|---|
| Jurkat | ALL‡ | — | — | — | — | — | — |
| MOLT-4 | ALL‡ | — | — | — | — | — | — |
| CCRF-CEM | ALL‡ | — | — | — | — | — | — |
| MT-2 | Cord1-153 | — | + | +++ | ++ | + | +++ |
| MT-4 | Cord1-153 | — | + | ++ | ++ | ++ | ++ |
| C5/MJ | Cord1-153 | — | + | + | + | ++ | ++ |
| SLB-1 | Normal1-153 | — | + | +++ | ++ | + | +++ |
| HUT-102 | ? | — | + | +++ | ++ | ++ | +++ |
| MT-1 | ATL | — | + | — | — | + | ++ |
| TL-OmI | ATL | — | + | — | — | + | ++ |
| ST-1 | ATL | + | + | — | — | + | + |
| SO-4 | ATL | + | + | — | — | + | + |
| KK-1 | ATL | + | + | — | — | + | ++ |
| Cell line . | Origin . | IL-2 dependency* . | HTLV-I provirus . | HTLV-I mRNA† . | Tax protein† . | JunD mRNA† . | AP-1 DNA binding† . |
|---|---|---|---|---|---|---|---|
| Jurkat | ALL‡ | — | — | — | — | — | — |
| MOLT-4 | ALL‡ | — | — | — | — | — | — |
| CCRF-CEM | ALL‡ | — | — | — | — | — | — |
| MT-2 | Cord1-153 | — | + | +++ | ++ | + | +++ |
| MT-4 | Cord1-153 | — | + | ++ | ++ | ++ | ++ |
| C5/MJ | Cord1-153 | — | + | + | + | ++ | ++ |
| SLB-1 | Normal1-153 | — | + | +++ | ++ | + | +++ |
| HUT-102 | ? | — | + | +++ | ++ | ++ | +++ |
| MT-1 | ATL | — | + | — | — | + | ++ |
| TL-OmI | ATL | — | + | — | — | + | ++ |
| ST-1 | ATL | + | + | — | — | + | + |
| SO-4 | ATL | + | + | — | — | + | + |
| KK-1 | ATL | + | + | — | — | + | ++ |
Dependency on IL-2 (10 ng/mL) in the culture medium for growth support.
Northern analysis of HTLV-I and JunD transcripts, Western analysis of Tax expression, and AP-1 DNA binding activity in cell lines, scored on a scale of 0 to 3+, with 0 being negative and 3+ being strongly positive.
ALL, acute lymphoblastic leukemia.
Established by cocultivation of normal cord blood or peripheral blood lymphocytes with HTLV-I infected cells.